Monsieur
Xavier NICOL
Chargé de recherche
Chercheur
ED158 3C

Molecular signals underlying the development of precise connectivity in the nervous system

23-02-2016
05-10-2016
26-04-2017
Available to host a PhD student
Integration of combinatorial guidance molecule signals in axonal growth cones for the development of neuronal connectivity.

Team

Xavier NICOL
The mature nervous system is an intricate network in which neurons are connected to specific partners. The choice of these partners is crucial for the correct behavior of the network (meaning the...

Biographie / Publications

Education

2015: Accreditation to supervise graduate student (HDR), University Paris 6
2006: PhD in Neuroscience, University Paris 7
2003: MSc in Neuropharmacology, University Paris 7
2002: Engineer of Ecole Polytechnique, Palaiseau, France


Research Experience

since 2012: Group leader, Institut de la Vision, Paris, France
since 2012: Tenured researcher, CNRS
2011-2012: Postdoctoral fellow, Patricia Gaspar lab, Institut du Fer à Moulin, Paris, France
2006-2010: Postdoctoral fellow, Nick Spitzer lab, University of California San Diego, USA
2003-2006: PhD student, Patricia Gaspar lab, Salpêtrière Hospital, Paris , France


Publications

Averaimo S, Assali A, Ros O, Couvet S, Zagar Y, Genescu I, Rebsam A, Nicol X. A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors. Nat Commun. 2016 Oct 3.

Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015 May 7.

Averaimo S, Nicol X. Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front Cell Neurosci. 2014 Nov 13.

Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri AR. Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry. 2015 Nov.

Nicol X, Gaspar P. Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases. Eur J Neurosci. 2014 Jun.

Plazas PV, Nicol X, Spitzer NC. Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3. Proc Natl Acad Sci U S A. 2013 Jan 22.

Voyatzis S, Muzerelle A, Gaspar P, Nicol X. Modeling activity and target-dependent developmental cell death of mouse retinal ganglion cells ex vivo. PLoS One. 2012.

Nicol X, Hong KP, Spitzer NC. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13776-81.

Hong KP, Spitzer NC, Nicol X. Improved molecular toolkit for cAMP studies in live cells. BMC Res Notes. 2011 Jul 20;4:241

Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P. cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map. Nat Neurosci. 2007 Mar;10(3):340-7.

Nicol X, Muzerelle A, Rio JP, Métin C, Gaspar P. Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction of exuberant retinal axons. J Neurosci. 2006 Jan 18;26(3):862-72.