Monsieur
Serge LUQUET
Directeur de recherche
Chercheur
ED 157

Central control of feeding behavior and energy expenditure

10-02-2016
10-02-2016
21-04-2017
Available to host a PhD student

Team

Serge LUQUET
Dans nos sociétés modernes, l’abondance de nourriture riche en énergie et le mode vie sédentaire entrainent un déséquilibre de la balance énergétique à l’origine du développement de l’obésité. Selon...

Biographie / Publications

Personal Statement

I received my PhD from the University of Nice Sophia Antipolis, France in 2003 in the laboratory directed by Dr Paul A Grimaldi. As a student I published seminal papers showing the role of PPAR delta in the control of muscle development and oxidative capability, and developed a strong knowledge in peripheral tissue metabolism & insulin sensitivity.  In 2003 I joined the laboratory of Professor Richard Palmiter (Howard Hughes Medical Institute & Department of Biochemistry) at the University of Washington. As a post-doc I focused primarily on the role of hypothalamic neurons that produce Agouti-related protein (AgRP) in the control of feeding behavior and further expanded my technical and conceptual skills in the field of molecular neuroendocrinology. I was recruited as an independent researcher by the French CNRS in 2006 and was awarded a young investigator research program where I now serve as group leader.  Since 2009 my group is established at the University Paris 7-Paris Diderot.

My group (http://www.bfa.univ-paris-diderot.fr/spip.php?rubrique81) integrates the use of modern molecular genetic tools and mouse models to dissect the role of discrete neural circuit elements in the control of energy balance and the central basis of the metabolic syndrome.  A recent achievement was to identify a novel role for a hypothalamic circuitry in AgRP-neurons in the coordination of efferent organ activity and nutrient partitioning, providing a mechanistic link between obesity and obesity-related disorders. In addition we recently demonstrated that when AgRP-neurons ‘activity is compromised through genetic, pharmacologic or dietary intervention (such as diet-induced obesity)-feeding behaviour is no longer dependent on metabolic demands but prominently rely on dopamine-encoded reward and leads to compulsive/comfort feeding. I have also developed unique technological approaches that will allow us to decipher the physiological basis of central lipid sensing. We demonstrate an unexpected role for brain lipid detection as possible mechanism for addictive-like behaviour associated with high fat diet.

I have successfully completed for a variety of funds, raising no less than 1.1 million euros in research contracts and grants since 2009. Although young, my group has already established strong national and international scientific networks based on our team’s recognition in the field of energy balance regulation.

My lab currently consists of 1 technicians, 1 research engineer, 2 engineer, 1 PhD student students. The techniques routinely used include viral-mediated genetic modification of brain nuclei, neurons-specific genetic disruption, in vivo indwelled chronic perfusion (carotid artery, jugular vein, intracerebroventricular), in vivo analysis of insulin sensitivity, microsurgery (catheter, cannula implant, vagal deafferentiation, bariatric surgery in mice), in vivo assessment of motivated behavior and positive reinforcement, in vivo assessment of metabolic efficiency and energy balance using fully automated and integrated indirect calorimetry (VO2, VCO2, RER), food intake & tropism, water intake, locomotor activity, telemetric recording of body temperature and cardiac rhythm, as well as tissue, feces & urine collection.

 

B. Positions and Honors

Positions and Employment

1999-2003                  Graduate student, University of Nice Sophia Antipolis, France (lab of P. Grimaldi )

2003-06                      Postdoctoral fellow University of Washington (lab of Richard Palmiter)

2006-present  Principal Investigator CNRS. Principal Investigator of a young research team in the University of Paris-Diderot-Paris 7 (http://www.bfa.univ-paris-diderot.fr/spip.php?rubrique81)

 

Professional Memberships

2007-               Ad hoc reviewer for Diabetes & Metabolism, Journal of Molecular Endocrinology, Experimental Diabetes Research, Journal of Neuroscience Research, Febs letter, EMBO J Molecular Metabolism, Frontiers in Neuroendocrinology

2007-              Neuroendocrinology society SNE (member)

2007-              European Association for the Study of Diabetes EASD (member)

2007-              French Society of Diabetes (member)

2010               European College of  Neuropsychopharmacology (ECNP) (member)

2010-              French association for the study of obesity (member)

2011-              Editor & Reviewer for Frontiers in Genomic Endocrinology

2012-              French Nutrition Society (member)

2012-              Consulting Editor of Molecular Metabolism

2014-              Members of the scientific advisory board of the Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Institute for Diabetes and Obesity (IDO), Munich, Germany. http://www.helmholtz-muenchen.de/ido/institute/advisory-board/index.html

2015-                          Scientific advisory board of the French Neuroendocrinology Society

2015-                          French Neuroscience Society

2015-                          Groupe d’Etude et de Recherche en Lipidomique (GERLI)

2016-                          Federation of European Neurosciences Society (FENS)

 

Honors and Awards

1999:-            National Merit Scholarship from French Department of National Education and Research.

2002-             Recipient of a Cancer Research Association (ARC) doctoral fellowship

2005-             Recipient of the Initiative Post-doc program fellowship.

2005-             Recipient Philippe Foundation fellowship.

2007-             Recipient of « Action Thématique et Incitative sur Programme », ATIP of CNRS.

2008-             Recipient of the USA/CNRS exchange program (2008-2010).

2009-             Funded by the National Research Agency (ANR)

2009-             Recipient of equipment program of the region île-de-France DIM

2009-             Recipient of the research grant ALFEDIAM-LILLY.

2010-             Recipient of a post-doctoral fellowship of the region île-de-France Domaine d’intérêt majeur DIM

2011-             Recipient of the grant « invited researcher program » from the University Paris Diderot Paris 7

2011-             Funded by the National Research Agency (ANR)

2011-             Recipient of « Action Thématique et Incitative sur Programme plus», ATIP plus of CNRS.

2012-                   Recipient of the research grant from the Société Francophone du Diabète-industrie

2015-              Nominated for the Helmholtz Young Investigator Diabetes Award (HeIDi)

 

 

International communication as invited speaker

2005               San Diego, USA : 65th Annual Meeting of the American Diabetes Association (ADA)

2006               Boston, USA: the 2006 Annual Scientific Meeting of NAASO, The Obesity Society

2007               Kobe, Japan: Kobe University Graduate School of Medicine

2007               Awaji Island, Japan: the 25th Japan Endocrine Society Summer Seminar

2009               Amsterdam, Netherlands: 8th Neuro-endo-psychology meeting

2010               Amsterdam, Netherlands: 23rd congress of the European College of Neuropsychopharmacology

2011               Geneva, Switzerland : 37thcongress of the Francophone society for Diabetes

2011               Quebec, Canada : 37th colloque of the  Société de NeuroEndocrinologie

2012               Heidelberg, Germany. he EMBO|EMBL Symposium Diabetes and Obesity

2013               Amsterdam, The Netherlands. international congress Nutrition, Metabolism and the Brain

2013               Copenhague, Danemark. Hagedorn insulin symposium,Novo Nordisk.

2014               Rennes, France. international conference « The affective Face of Desire »

2014               Amsterdam, The Netherlands. 12th Endo-Neuro-Psycho meeting

2014               Sydney, Australia.International congress of Neuroendocrinology (ICN) 2014

2014               Rennes, France. 27th Conference of European Comparative Endocrinologists 2014

2014               Berlin, Germany. German French Conference on Diabetes Research

2015               Paris, France. “Journee Chevreuil 2015” Lipids & Brain 3. French Society for the Study of Lipids

2015               Leipzig, Germany. 1st Leipzig International Meeting for Interdisciplinary Obesity Research (LIMIOR)

2015               Munich, Germany. 3rd Annual Helmholtz-­‐Nature Medicine Diabetes Conference

2015               Munich, Germany- Mini-symposium “Metabolic Principles of Physiology and Disease”

 

C. Contribution to Science

 

1. My early publication primarily focused on the role of a lipid-activated transcription factor Peroxisome-proliferated activated receptor delta (PPARdelta) in the overall differentiation program and fate of adipogenic and muscle cells. I have demonstrated for the first time the role of PPARd in the establishment of oxidative capabilities of muscle cells. This work pioneered the role of PPARd as a potential pharmacological target for muscle function and metabolism.

 

a. Luquet, S., Lopez-Soriano, J., Holst, D., Gaudel, C., Jehl-Pietri, C., Fredenrich, A., and Grimaldi, P. A. (2004). Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome. Biochimie 86, 833-837. (IF 2014: 2.963)

b. Luquet, S., Lopez-Soriano, J., Holst, D., Fredenrich, A., Melki, J., Rassoulzadegan, M., and Grimaldi, P. A. (2003). Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. Faseb J 17, 2299-2301. (IF2014: 5.043)

c. Holst, D., Luquet, S., Nogueira, V., Kristiansen, K., Leverve, X., and Grimaldi, P. A. (2003). Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. Biochim Biophys Acta 1633, 43-50.

 

2. In a second step of my career I have demonstrated the role of hypothalamic orexigenic neurons that produced NPY and AgRP as critical for the central regulation of food intake. I also highlighted the potential network based compensatory mechanism that occurs during development in hypothalamic network involved in energy balance regulation. Extending further the role of these neurons, I have demonstrated their implication at a central coordinator of peripheral nutrient partitioning i. e the storage, utilization or transformation of nutrient through the coordinated regulation of autonomic inputs onto pancreas, muscle and liver. Finally I could demonstrated the concept that NPY/AgRP neurons are critical regulator of food intake in response to metabolic demands and that pharmacologic, physiologic or genetic inhibition of their activity leads to aberrant feeding behavior essentially driven by reward and palatability.

 

a.  Luquet, S., Perez, F. A., Hnasko, T. S., and Palmiter, R. D. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685.

b. Joly-Amado, A., Denis, R.G., Castel, J., Lacombe, A., Cansell, C., Rouch, C., Kassis, N., Dairou, J., Cani, P.D., Ventura-Clapier, R., Prola, A., Flamment, M., Foufelle, F.,Magnan, C., Luquet, S. (2012). Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J 31:4276-4288.

c.  Denis, RG., Joly, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S., Cansell, C., Dehouck, B., Castel, J., Delbes, AS., Martniez, S.,Lacombe, A., Rouch, C., Kassis, N., Fehrentz,J-A., Martinez, J, Verdié, P., Hnasko, T, Palmiter, RD., Krashes, MJ., Güler, A., Magnan, C., Luquet, S (2015). Palatability can drive feeding independent of AgRP neurons. Cell Metab 22, 646-657

 

3. Lipid sensing in the brain has been critically involved in hypothalamic regulation of energy balance. However beside free fatty acids, circulating triglyceride (TG) are the second major source of nutritional lipids. The bran express at high level the enzyme involved in processing TG and I could demonstrate that nutritional structure TG can be detected by the mesolimbic “reward” circuit to regulate reward seeking behavior and especially food reward. This discovery provides an overall new framework to connect nutritional change and the compulsive/addictive behavior resulting from calories-dense food.

 

a.         Cansell, C., Castel, J., Denis, R., Rouch, C., Delbes, AS., Martinez, S., Mestivier, D., Finan, B., Maldonado-Aviles, J.G, Rijnsburger, M.,  Tschöp, M.H., DiLeone, R.J., Eckel, R.H., La Fleur, S., Magnan, C., Hnasko, T., Luquet., S (2014). Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry 19, 1095-1105.

b.         Magnan, C., Levin, B.E., and Luquet, S. (2015). Brain lipid sensing and the neural control of energy balance. Mol Cell Endocrinol 418 Pt 1, 3-8

c.         Cansell, C., Luquet, S. (2015). Triglyceride sensing in the reward circuitry: a new insight in feeding behavior regulation. Biochimie 120, 75-80.

 

Complete List of Published Work in MyBibliography:   http://www.ncbi.nlm.nih.gov/sites/myncbi/1XCLbZcZv5qA9/bibliography/49529679/public/?sort=date&direction=ascending.



Published Manuscript

 

 

  1. Denis, RG., Joly, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S., Cansell, C., Dehouck, B., Castel, J., Delbes, AS., Martniez, S.,Lacombe, A., Rouch, C., Kassis, N., Fehrentz,J-A., Martinez, J, Verdié, P., Hnasko, T, Palmiter, RD., Krashes, MJ., Güler, A., Magnan, C., Luquet, S(2015). Palatability can drive feeding independent of AgRP neurons. Cell Metab 22, 646-657. (IF 2014 :17.565)

a. http://www2.cnrs.fr/presse/communique/4165.htm

b. http://www.univ-paris-diderot.fr/sc/site.php?bc=accueil&np=pageActu&ref=7488

  1. Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H.L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R.G., Ancel, P., Lacombe, A., Ling, Y., Allatif, O., Cruciani-Guglielmacci, C., Andre, S., Viguerie, N., Poitou, C., Stich, V., Torcivia, A., Foufelle, F., Luquet, S., Aron-Wisnewsky, J., Langin, D., Clement, K., Udalova, I.A., and Venteclef, N. (2015). Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med 21, 610-618. (IF2014: 27.363)
  2. Geurts, L., Everard, A., Van Hul, M., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., Castel, J., Denis, R.G., Bergiers, M., Druart, C., Alhouayek, M., Delzenne, N.M., Muccioli, G.G., Demoulin, J.B., Luquet, S., and Cani, P.D. (2015). Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nature communications 6, 6495 (IF2014: 11.47)
  3. Everard, A., Geurts, L., Caesar,R., Matamoros, S., Duparc, T., Denis, R., Cochez, R., Pierard, F., Castel, J., B. Bindels, L., Robine,S., G. Muccioli, G., Renauld,JC., Dumoutier, L., Delzenne, N., Luquet, S., Backhed, F., Cani, P. Intestinal epithelial MyD88 is a sensor switching host metabolism during diet induced obesity. (2014). Manuscript accepted in Nature communication. (IF2014: 11.47)
  4. Mouisel, E., Hourde, C., Karima Relizani, C., Mille-Hamard, L., Denis, R., Agbulut, O., Jülich, K., Arandel, L., Vignaud, A.,  Garcia, L., Ferry, A., Luquet, S., Billat, V., Bendahan Ventura-Clapier, R.,  Schuelke, M., and Amthor, H. (2014). Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol 307, R444-454. (IF2014: 3.106)
  5. Tavernier, A., Le Galla, M., Ducroca, R., Denis, G. P. R,  Cluzeauda, F., Sakar, Y., Guilmeau, S., Hindlet, P., Nazareta, C., Barbot, L., Kapel, N., Le Beyeca, J., Jolya, F., Chuah, S., Aparicio, T., Luquet, S., Bado, A.  (2014). Intestinal Deletion of Leptin Signaling Alters Activity of Nutrient Transporters and Delayed the Onset of Obesity in Mice. Faseb J. (IF2014: 5.043)
  6. Cansell, C., Castel, J., Denis, R., Rouch, C., Delbes, AS., Martinez, S., Mestivier, D., Finan, B., Maldonado-Aviles, J.G, Rijnsburger, M.,  Tschöp, M.H., DiLeone, R.J., Eckel, R.H., La Fleur, S., Magnan, C., Hnasko, T., Luquet., S(2014). Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry 19, 1095-1105. (IF2014: 14.496)
    1. http://www2.cnrs.fr/presse/communique/3511.htm
    2. http://www.univ-paris-diderot.fr/sc/site.php?bc=accueil&np=pageActu&ref=6111
    3. http://www.huffingtonpost.fr/2014/04/15/obesite-cerveau-graisses-drogues-dures_n_5145589.html?utm_hp_re=france
    4. https://destinationsante.com/le-gras-drogue-dure-pour-le-cerveau.html
    5. Parnaudeau, S., Dongelmans, ML., Turiault, M., Ambroggi, F., Delbes, AS., Cansell, C., Luquet, S., Piazza, P. V., Tronche, F & Barik J. (2014). Glucocorticoid receptors in dopaminoceptive neurons facilitate the sensitizing and rewarding properties of amphetamine with no effect on responses to food reward. Front Behav Neurosci 8, 35. (IF 2014 :3.270)
    6. Beranger, G., Pisani, F, D., Castel, J., Djedaini, M., Battaglia, S., Amiaud, J., Boukhechba, F., Ailhaud, G., Michiels, J F., Heymann, D.,  Luquet, S and Amri E,Z. (2014). Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. Endocrinology 155, 1340-1352. (IF 2014 :4.503)
    7. Picard, A, Rouch, C., Kassis, N., Moullé, S,M, Croizier, S., Denis, RG., Castel, J., Coant, N., Davis, K., Clegg, DJ., Benoit S C., Le Stunff, H, Luquet, S., Prévot, V., Bouret, S., Cruciani-Guglielmacci, C., Magnan, C. (2014) Hippocampal lipoprotein lipase regulates energy balance in rodents. Mol Metab 3, 167-176.. (IF : pas encore d’impact)
    8. Lehti, M., Donelan, E., Abplanalp, W, Al-Massadi, O., Habegger, K., Weber, J., Ress, J, Mansfeld, J., Somvanshi, S., Trivedi, C., Keuper, M., Ograsjek, T., Striese, C, Cucuruz, S, Pfluger, P. T., Krishna, R.,  Gordon, S.M., D. Silva R. A. G., Luquet, S., Castel, J., Martinez, S.,  D’Alessio, D., Davidson, W. S., Hofmann, S (2013). High-density lipoprotein levels maintain skeletal muscle function by modulating cellular respiration in mice. Circulation 2013; 128(22): 2364-2371. (IF 2014: 14.430)
    9.  (*2nd co Authorship). Langlet, F., Levin, B.E*., Luquet, S*., Mazzone, M*., Messina, A*., Dunn-Meynell, A.A., Balland, E., Lacombe, A., Mazur, D., Carmeliet, P., Bouret, S.G., Prevot, V., and Dehouck, B. (2013). Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting. Cell metabolism 17, 607-617. (IF 2014 :17.565)
    10. Joly-Amado, A., Denis, R.G., Castel, J., Lacombe, A., Cansell, C., Rouch, C., Kassis, N., Dairou, J., Cani, P.D., Ventura-Clapier, R., Prola, A., Flamment, M., Foufelle, F.,Magnan, C., Luquet, S. (2012). Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J 31:4276-4288. . (IF 2014: 10.434)
      1. http://www.embo.org/news-a-media-centre/press-releases/brain-neurons-and-diet-influence-onset-of-obesity-and-diabetes-in-mice.html
      2. http://www2.cnrs.fr/presse/communique/2783.htm
      3. http://www.univ-paris-diderot.fr/sc/site.php?bc=accueil&np=pageActu&ref=4409
      4. Serino, M., Waget, A., Marsollier, N., Masseboeuf, M., Payros, G., Kabani, C., Denom, J., Lacombe, A., Thiers, J.C., Negre-Salvayre, A., Luquet, S., Burcelin, R., Cruciani-Guglielmacci, C., and Magnan, C. (2011). Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. PloS one 6:e21184. (IF 2014: 3.234)
      5. Vernia, S., Heredia, M., Criado, O., Rodriguez de Cordoba, S., Garcia-Roves, P.M., Cansell, C., Denis, R., Luquet, S., Foufelle, F., Ferre, P., et al. (2011). Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice. Human molecular genetics 20:2571-2584. (IF 2014: 6.393)
      6. Pillot, B., Duraffourd, C., Begeot, M., Joly, A., Luquet, S., Houberdon, I., Naville, D., Vigier, M., Gautier-Stein, A., Magnan, C., et al. (2011). Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. PLoS One 6:e19107. (IF 2014: 3.234)
      7. Sabra-Makke, L., Tourrel-Cuzin, C., Denis, R.G., Moldes, M., Pegorier, J.P., Luquet, S., Vasseur-Cognet, M., and Bossard, P. (2010). The nutritional induction of COUP-TFII gene expression in ventromedial hypothalamic neurons is mediated by the melanocortin pathway.PLoS One 5:e13464. (IF 2014: 3.234)
      8. Massiera, F., Barbry, P., Guesnet, P., Joly, A., Luquet, S., Moreilhon-Brest, C., Mohsen-Kanson, T., Amri, E.Z., and Ailhaud, G. (2010). A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations. J Lipid Res 51:2352-2361. (IF 2014: 4.421)
      9. Karaca, M., Castel, J., Tourrel-Cuzin, C., Brun, M., Geant, A., Dubois, M., Catesson, S., Rodriguez, M., Luquet, S., Cattan, P., et al. Exploring Functional beta-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker (2009). PLoS ONE 4:e5555. (IF 2014: 3.234)
      10. Kammoun, H.L., Chabanon, H., Hainault, I., Luquet, S., Magnan, C., Koike, T., Ferre, P., and Foufelle, F. (2009). GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J Clin Invest 119:1201-1215. (IF 2014: 13.215)
      11. Hernandez Vallejo, S.J., Alqub, M., Luquet, S., Cruciani-Guglielmacci, C., Delerive, P., Lobaccaro, J.M., Kalopissis, A.D., Chambaz, J., Rousset, M., and Lacorte, J.M. (2009). Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet. Am J Physiol Gastrointest Liver Physiol 296:G782-792. (IF 2014: 3.798)
      12. Liu, J., Wang, L., Harvey-White, J., Huang, B.X., Kim, H.Y., Luquet, S., Palmiter, R.D., Krystal, G., Rai, R., Mahadevan, A., et al. (2008). Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 54:1-7. (IF 2014: 4.877)
      13. Luquet, S., Phillips, C.T., and Palmiter, R.D. (2007). NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28:214-225. (IF 2014: 2.618)
      14. Weydt, P., Pineda, V.V., Torrence, A.E., Libby, R.T., Satterfield, T.F., Lazarowski, E.R., Gilbert, M.L., Morton, G.J., Bammler, T.K., Strand, A.D., Cui, L.Beyer, R. P., Easley, C. N., Smith, A. C., Krainc, D., Luquet, S., Sweet, I. R., Schwartz, M.W., La Spada, A. R. (2006). Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab 4:349-362. (IF 2014 :17.565)
      15. Hnasko, T. S., Perez, F. A., Scouras, A. D., Stoll, E. A., Gale, S. D., Luquet, S., Phillips, P. E., Kremer, E. J., and Palmiter, R. D. (2006). Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A 103, 8858-8863. (IF 2014: 9.674)
      16. Marie, L.S., Luquet, S., Cole, T.B., and Palmiter, R.D. (2005). Modulation of neuropeptide Y expression in adult mice does not affect feeding. Proc Natl Acad Sci U S A 102:18632-18637. (IF 2014: 9.674)
      17. Luquet, S., Perez, F. A., Hnasko, T. S., and Palmiter, R. D. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685. (IF 2014: 33.611)
      18. Ste Marie, L., Luquet, S., Curtis, W., and Palmiter, R. D. (2005). Norepinephrine- and epinephrine-deficient mice gain weight normally on a high-fat diet. Obes Res (obesity)13, 1518-1522. (IF 2014: 4.953)
      19. Gillot, I., Jehl-Pietri, C., Gounon, P., Luquet, S., Rassoulzadegan, M., Grimaldi, P., and Vidal, F. (2005). Germ cells and fatty acids induce translocation of CD36 scavenger receptor to the plasma membrane of Sertoli cells. J Cell Sci 118, 3027-3035. (IF 2014: 5.432)
      20. Luquet, S., Gaudel, C., Holst, D., Lopez-Soriano, J., Jehl-Pietri, C., Fredenrich, A., and Grimaldi, P. A. (2005). Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes. Biochim Biophys Acta 1740, 313-317. (IF 2014: 2.59)
      21. Luquet, S., Lopez-Soriano, J., Holst, D., Gaudel, C., Jehl-Pietri, C., Fredenrich, A., and Grimaldi, P. A. (2004). Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome. Biochimie 86, 833-837. (IF 2014: 2.963)
      22. Luquet, S., Lopez-Soriano, J., Holst, D., Fredenrich, A., Melki, J., Rassoulzadegan, M., and Grimaldi, P. A. (2003). Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. Faseb J 17, 2299-2301. (IF2014: 5.043)
      23. Holst, D., Luquet, S., Kristiansen, K., and Grimaldi, P. A. (2003). Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation. Exp Cell Res 288, 168-176. (IF 2014 : 3.246)
      24. Holst, D., Luquet, S., Nogueira, V., Kristiansen, K., Leverve, X., and Grimaldi, P. A. (2003). Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. Biochim Biophys Acta 1633, 43-50. (IF 2014: 2.59)
      25. Jehl-Pietri, C., Bastie, C., Gillot, I., Luquet, S., and Grimaldi, P. A. (2000). Peroxisome-proliferator-activated receptor delta mediates the effects of long-chain fatty acids on post-confluent cell proliferation. Biochem J 350 Pt 1, 93-98. (IF 2014: 4.396)
      26. Bastie, C., Luquet, S., Holst, D., Jehl-Pietri, C., and Grimaldi, P. A. (2000). Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. J Biol Chem 275, 38768-38773. (IF 2014: 4.573)
  1. Gao, Y., Tschöp, M.H., Luquet,S. (2014). Hypothalamic Tanycytes: Gatekeepers to metabolic control. Cell Metabolism 19,173-175 (IF 2014 :17.565)

 

Review

 

 

 

  1. Magnan, C., Levin, B.E., and Luquet, S. (2015). Brain lipid sensing and the neural control of energy balance. Mol Cell Endocrinol 418 Pt 1, 3-8. (IF 2014: 4.4)
  2. Cansell, C., Luquet, S. (2015). Triglyceride sensing in the reward circuitry: a new insight in feeding behavior regulation. Biochimie 120, 75-80. (IF 2014: 2.963)
  3. Moulle, V.S., Picard, A., Cansell, C., Luquet, S., and Magnan, C. (2015). Role of brain lipid sensing in nervous regulation of energy balance. Med Sci (Paris) 31, 397-403. (IF 2014: 0.671)
  4. Magnan, C & Luquet, S. Lipid sensing in the brain and regulation of energy balance (2014). Molecular and Cellular Endocrinology, In press. (IF 2014: 4.405)
  5. Picard, A., Moulle, V.S., Le Foll, C., Cansell, C., Veret, J., Coant, N., Le Stunff, H., Migrenne, S., Luquet, S., Cruciani-Guglielmacci, C., et al. (2014). Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes Obes Metab 16 Suppl 1, 49-55. (IF 2014: 6.36)
  6. Joly-Amado, A., Cansell, C., Denis, R.G., Delbes, A.S., Castel, J., Martinez, S., and Luquet, S. (2014). The hypothalamic arcuate nucleus and the control of peripheral substrates. Best Pract Res Clin Endocrinol Metab 28, 725-737. (IF 2014: 4.602)
  7. Denis, RGP., Joly-Amado A., Cansell, C., Castel, J, Martinez, S., Delbes, AS., Luquet, S. (2014) Central orchestration of peripheral nutrient partionning and substrate utilization: implication for the metabolic syndrome. Diabetes Metab 40, 191-197.. (IF 2014: 3.267)
  8. Cansell, C., Luquet, S. (2014). La détection centrale des lipides et la régulation du comportement alimentaire : implication dans l’obésité/Central lipid detection and the regulation of feeding behavior : inplication in obesity. les Cahiers de nutrition et de diététique (2014). (IF 2012: pas d’impact) 49, 32 – 43.
  9. Cansell, C., Luquet, S. Central lipid detection and the regulation of feeding behavior. (2013). review. Oléagineux Corps gras Lipides. OCL. Vol 20 N°2 mars-avril 2013. 93-101. (IF 2012: pas d’impact)
  10. Denis, RGP.,Cansell, C., Castel, J., Luquet, S. Circuits de la récompense et prise alimentaire/ Reward neurocircuitry and food intake. (2013). Médecine des maladies Métaboliques – 7,13-21. (IF 2012: pas d’impact)
  11. Cansell, C., Denis, R.G., Joly-Amado, A., Castel, J., and Luquet, S. (2012). Arcuate AgRP neurons and the regulation of energy balance. Frontiers in Endocrinology 3:169. (IF 2012: pas encore d’impact)
  12. Cansell C, Luquet S. (2012). Hypothalamic regulation of energy balance:a key role for DICERmiRNA processing in arcuate POMC neurons. Molecular Metabolism 2, 55-57. (IF 2012: pas encore d’impact)
  13. Moulle, V.S., Cansell, C., Luquet, S., and Cruciani-Guglielmacci, C. (2012). The multiple roles of fatty acid handling proteins in brain. Front Physiol 3:385. (IF 2012: pas encore d’impact)
  14. Luquet, S., Cruciani-Guglielmacci, C. (2009).Le contrôle central de la balance énergétique. Cahier de nutrition et de diététique (2009) 44, 17—25. (IF 2013: pas d’impact)
  15. Luquet, S., and Magnan, C. (2009). The central nervous system at the core of the regulation of energy homeostasis.Front Biosci (Schol Ed) 1:448-465. (IF 2014: 3.736)
  16. Luquet, S., Marsollier, N., Cruciani-Guglielmacci, C., Magnan, C. (2008). Les signaux de la régulation du comportement alimentaire. Obésité. 3, 167-176. (IF 2012: pas d’impact)
  17. Luquet, S. (2008). What’s new in the regulation of eating? Med Sci (Paris) 24, 680-682. (IF 2013: 0.556)
  18. Luquet, S., Marsollier, N., Cruciani-Guglielmacci, C. (2008). Les signaux de l’appétit et de la satiété. Médecine Clinique endocrinologie & diabète. 34, 38-44. (IF 2012: pas d’impact)
  19. Luquet, S., Régulation de la prise alimentaire, Food intake regulation. (2008). Nutrition Clinique et Métabolisme. 22, 52-58. Actes de congrès de VIIIe Symposium nutrition. (IF 2012: 0.621)
  20. Luquet, S. (2007). Acides gras et système nerveux central. Nutrition, Aliments Fonctionnels Aliments Santé (NAFAS) 5, N° 6 Décembre 2007.  Actes de congrès de l’Université d’été de nutrition.