Monsieur
Peter VANHOUTTE
Directeur de recherche
Chercheur
ED3C
03-03-2015
20-02-2015
20-10-2016
Available to host a PhD student
Role of dopamine and glutamate receptor heteromers in cocaine addiction

Team

 Nos principaux intérêts de recherche concernent l’étude des événements intracellulaires qui gouvernent la plasticité neuronale et les adaptations comportementales à long terme. Nous étudions le...

Biographie / Publications

 Research Experience

2014-present : CNRS/DR2 co-director or the team « Neuronal Signaling and Gene Regulations » ; Université Pierre et Marie Curie – Paris VI- laboratory  Neuroscience Paris-Seine (Director Hervé Chneiweiss)

2010-2013: CNRS/CR1 researcher-co-head of the group “ Intracellular Signaling and Neuroadaptation”. (Director Bruno Giros)

2007-2009: Research fellow at the CNRS; CR1; UMR7224/UMRS-952; Habilitation à Diriger les Recherches (HDR) passed in November 2009.

2003 : Research Fellow at CNRS; CR2; UMR 7102 (Director Pr Jean Mariani).

2000-2002 : Post-doctoral position in Dr Hilmar Bading’s group (Medical Research Council Cambridge, UK) : Study of Calcium-dependent signaling in hippocampal neurons  and at the department of Neurosciences at the University of Heidelberg (Dr Hilmar Bading).

Selected publications:

Cahill E, Pascoli V, Trifilieff P, Savoldi D, Kappès V, Lüscher C, Caboche J, Vanhoutte P (2014) D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signaling to control plasticity and cocaine-induced responses. Mol. Psychiatry. doi: 10.1038/mp.2014.73.

Pascoli V, Cahill E, Bellivier F, Caboche J, Vanhoutte P (2014) Extracellular signal-Regulated kinases 1 and 2 activation by addictive drugs: A signal toward pathological adaptation. Biol. Psychiatry. doi: 10.1016/j.biopsych.2014.04.005.

Heck N, Betuing S, Vanhoutte P, Caboche J (2012) A method for automated 3D- analysis of dendritic spines allows for early detection of spine density alteration in R6/2 mouse model of Huntington’s Disease. Brain Struct. Funct. 217:421-434.

Peyrin JM, Deleglise B, Saias L, Vignes M, Gougis P, Magnifico S, Betuing S, Pietri M, Caboche J, Vanhoutte P, Viovy JL, Brugg B (2012) Axon Diodes for the reconstruction of oriented neuronal networks in microfluidic chambers. Lab on Chips 11:3663-3673.

Pascoli V, Besnard A, Hervé D, Heck N, Pagès C, Girault JA, Caboche J, Vanhoutte P (2011) cAMP-independent tyrosine phosphorylation of NR2B mediates cocaine-induced Extracellular signal-Regulated (ERK) activation. Biol Psychiatry 69:218-227.

Pascoli V, Besnard A, Hervé D, Heck N, Pagès C, Girault JA, Caboche J, Vanhoutte P (2011) cAMP-independent tyrosine phosphorylation of NR2B mediates cocaine- induced Extracellular signal-Regulated (ERK) activation. Biol Psychiatry 69:218-227.

Besnard A, Bouveyron N, Kappès V, Pascoli V, Pagès C, Heck N, Vanhoutte P, Caboche J (2011) Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation. J Neurosci 31:14296-14307.