Research Experience

2014-present : CNRS/DR2 co-director or the team « Neuronal Signaling and Gene Regulations » ; Université Pierre et Marie Curie – Paris VI- laboratory  Neuroscience Paris-Seine (Director Hervé Chneiweiss)

2010-2013: CNRS/CR1 researcher-co-head of the group “ Intracellular Signaling and Neuroadaptation”. (Director Bruno Giros)

2007-2009: Research fellow at the CNRS; CR1; UMR7224/UMRS-952; Habilitation à Diriger les Recherches (HDR) passed in November 2009.

2003 : Research Fellow at CNRS; CR2; UMR 7102 (Director Pr Jean Mariani).

2000-2002 : Post-doctoral position in Dr Hilmar Bading’s group (Medical Research Council Cambridge, UK) : Study of Calcium-dependent signaling in hippocampal neurons  and at the department of Neurosciences at the University of Heidelberg (Dr Hilmar Bading).

Selected publications:

Cahill E, Pascoli V, Trifilieff P, Savoldi D, Kappès V, Lüscher C, Caboche J, Vanhoutte P (2014) D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signaling to control plasticity and cocaine-induced responses. Mol. Psychiatry. doi: 10.1038/mp.2014.73.

Pascoli V, Cahill E, Bellivier F, Caboche J, Vanhoutte P (2014) Extracellular signal-Regulated kinases 1 and 2 activation by addictive drugs: A signal toward pathological adaptation. Biol. Psychiatry. doi: 10.1016/j.biopsych.2014.04.005.

Heck N, Betuing S, Vanhoutte P, Caboche J (2012) A method for automated 3D- analysis of dendritic spines allows for early detection of spine density alteration in R6/2 mouse model of Huntington’s Disease. Brain Struct. Funct. 217:421-434.

Peyrin JM, Deleglise B, Saias L, Vignes M, Gougis P, Magnifico S, Betuing S, Pietri M, Caboche J, Vanhoutte P, Viovy JL, Brugg B (2012) Axon Diodes for the reconstruction of oriented neuronal networks in microfluidic chambers. Lab on Chips 11:3663-3673.

Pascoli V, Besnard A, Hervé D, Heck N, Pagès C, Girault JA, Caboche J, Vanhoutte P (2011) cAMP-independent tyrosine phosphorylation of NR2B mediates cocaine-induced Extracellular signal-Regulated (ERK) activation. Biol Psychiatry 69:218-227.

Pascoli V, Besnard A, Hervé D, Heck N, Pagès C, Girault JA, Caboche J, Vanhoutte P (2011) cAMP-independent tyrosine phosphorylation of NR2B mediates cocaine- induced Extracellular signal-Regulated (ERK) activation. Biol Psychiatry 69:218-227.

Besnard A, Bouveyron N, Kappès V, Pascoli V, Pagès C, Heck N, Vanhoutte P, Caboche J (2011) Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation. J Neurosci 31:14296-14307.