Development of the neocortical connectivity
Dates:2 January 2018 - 29 June 2018
Date limite de candidature:29 June 2018
~ Jan-March 2018
~ April-June 2018
In mammals, the cerebral cortex is organized in distinct functional areas, allowing the processing of sensory and motor information and the control of cognitive functions. In particular, the neocortex is connected to the rest of the central nervous system by a major structure: the internal capsule, a compact axonal tract organized in the three-dimensional space and composed of different axonal populations.
The project proposed aims to better understand the formation of the internal capsule in mouse embryonic development by 1) characterizing the role of the major known classes of guidance molecules in axon/axon contacts and 2) analyzing the spatial and temporal development of the internal capsule in wild and mutant conditions through an innovative method combining immunohistochemistry with tissue transparency.
This project involves the use of powerful and innovative techniques that will open up new perspectives in understanding the mechanisms involved in cerebral wiring.