Brain Development and Plasticity

Leader

Research center

45 rue d’Ulm
75230 Paris
Marc Mézard

Institution

Ecole Normale Supérieure
Inserm
CNRS
ED 515 Complexité du Vivant
Université Pierre et Marie Curie

Laboratory

Institut de Biologie de l'ENS IBENS
Phone: 01 44 32 35 47
U1024 - UMR8197
Memolife, PSL

Mots clefs

Développement cérébral
inflammation prénatale
génétique de la souris
microglies
migration et guidage axonal
Available to host a PhD student

publications

de Frutos CA, Bouvier G, Arai Y, Thion MS, Lokmane L, Keita M, Garcia-Dominguez M, Charnay P, Hirata T, Riethmacher D, Grove EA, Tissir F, Casado M, Pierani A, Garel S. Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron. 2016 Oct 19;92(2):435-448. doi: 10.1016/j.neuron.2016.09.020. 

Lokmane L, Garel S. Map transfer from the thalamus to the neocortex: inputs from the barrel field. Semin Cell Dev Biol. 2014 Nov;35:147-55. doi: 10.1016/j.semcdb.2014.07.005. Epub 2014 Jul 11.


Deck M, Lokmane L, Chauvet S, Mailhes C, Keita M, Niquille M, Yoshida M, Yoshida Y, Lebrand C, Mann F, Grove EA, Garel S. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 6;77(3):472-84. doi: 10.1016/j.neuron.2012.11.031.

Lopez-Bendito*, G., Cautinat*, A., Sanchez, J.A., Bielle, F., Flames, N., Garrat, A.N., Talmage, D., Role, L.W., Charnay, P., Marin*, O. & Garel*, S. Tangential neuronal migration controls axon guidance : a role for neuregulin-1 in thalamocortical axon navigation. (2006) Cell, 125(1):127-42.

Storm*, E.E., Garel*, S., Borello*, U., Hebert, J.M., Martinez, S., McConnell, S.K., Martin, G.R. & Rubenstein, J.L.R. (2006) Dosage dependent functions of Fgf8 in regulating telencephalic patterning centers. (2006) Development, 133, 1831-44.

Garel, S. & Rubenstein, J.L.R., (2005). Patterning of the cerebral cortex. Cognitive Neuroscience III, (Gazzaniga MS, ed). Cambridge: MA, MIT Press.

Huffman, K.J., Garel, S. & Rubenstein, J.L.R., (2004). Fgf8 regulates the development of intra-neocortical projections. J. Neurosci., 24, 8917-8923.

Garel, S. & Rubenstein, J.L.R., (2004). Intermediate targets in the formation of topographic projections: inputs from the thalamocortical system. Trends Neurosci., 27, 533-39.

Fields of research

Neurogenetics / neurodevelopment

Research Theme

The long-term goal of our laboratory is to understand how the anterior part of the mammalian brain, the telencephalon, is shaped and wired during development. The telencephalon, comprising the cerebral cortex and basal ganglia, plays essential roles such as motor control, sensory perception, and cognitive functions. Its complex neuronal networks are assembled during embryogenesis and remodeled during early postnatal life. During this process, both cell migration and axon guidance play essential roles by controlling the accurate positioning of neuronal subtypes and the formation of specific connections, respectively. Whereas conserved sets of factors have been shown to control cell migration and axon guidance, there is still much to learn about how these two fundamental processes are controlled and coordinated to ensure the morphogenesis of neural circuits in vivo.

By combining mouse molecular genetics, ex-vivo manipulations and advanced imaging techniques, we investigate how cell migration and axon pathfinding are controlled and coordinated to ensure the morphogenesis of neural networks in the developing telencephalon. As developmental abnormalities participate in the etiology of several neuropsychiatric disorders, understanding how the telencephalon wires is essential not only to gain insights into its normal functioning, but also to advance our comprehension of neuropsychiatric disorders. 

Etudiants ENP

Andrea TINTERRI

Membres de l'équipe

ALVAREZ DE FRUTOS Cristina
DECK Marie
KEITA Maryama
LOKMANE Ludmilla
OLLER Guilaume
SQUARZONI Paola

Lab rotation

Development of the neocortical connectivity

Chercheur responsable: 

GAREL Sonia

Dates: 

2 January 2018 - 29 June 2018

Date limite de candidature: 

29 June 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

In mammals, the cerebral cortex is organized in distinct functional areas, allowing the processing of sensory and motor information and the control of cognitive functions. In particular, the neocortex is connected to the rest of the central nervous system by a major structure: the internal capsule, a compact axonal tract organized in the three-dimensional space and composed of different axonal populations. 

The project proposed aims to better understand the formation of the internal capsule in mouse embryonic development by 1) characterizing the role of the major known classes of guidance molecules in axon/axon contacts and 2) analyzing the spatial and temporal development of the internal capsule in wild and mutant conditions through an innovative method combining immunohistochemistry with tissue transparency.

This project involves the use of powerful and innovative techniques that will open up new perspectives in understanding the mechanisms involved in cerebral wiring.

Contact

Ecole Normale Supérieure - IBENS - 46 rue d’Ulm 75005 Paris - +33 1 44 32 37 18 / +33 1 44 32 37 25 - garel@biologie.ens.fr/ lokmane@biologie.ens.fr

Superviseur: 

GAREL Sonia & LOKMANE Ludmilla