Cortical dynamics and coding mechanisms


Research center

45 rue d’Ulm
75230 Paris
Marc Mézard


Ecole Normale Supérieure
Université Pierre et Marie Curie


Institut de Biologie de l'ENS IBENS
U1024 UMR8197
Labex Memolife, Programme France Bio-Imaging

Mots clefs

Integrative neuroscience
Tactile sensory modality
Barrel cortex
Two-photon fluorescence microscopy
Adaptive optics
Available to host a PhD student


Wang J., Leger J.-F., Binding J., Boccara C., Gigan S., Bourdieu L., Measuring aberrations in the rat brain by coherence-gated wavefront sensing using a Linnik(2012)

J. Ben Arous, J. Binding, J.-F. Léger, M. Casado, S. Gigan, C. Boccara, L. Bourdieu. Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy J. Biomed. Opt. 16(11) 116012. (2011)

Y. Kremer, J.-F. Léger, D. Goodman, R. Brette, L. Bourdieu. Late maturation of the vibrissae direction selectivity map in the rat barrel cortex. J. Neurosci. 31(29) 10689 –10700. (2011)

J. Binding, J. Ben Arous, J.-F. Léger, S. Gigan, C. Boccara and L. Bourdieu. Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and its consequence on two-photon microscopy. Opt. Express, 19(6) 4833-47.  (2011)

Y. Kremer, J.-F. Léger, R. Lapole, N. Honnorat, Y. Candela, S. Dieudonné and L. Bourdieu A spatio-temporally compensated acousto-optic scanner for two-photon microscopy providing large field of view. Opt. Express 16(14), 10066-10076.(2008) 

Fields of research

Neurophysiology / systems neuroscience

Research Theme

We study the representation of sensory information in a cortical column by recording optically the activity of tens to thousands of neurons. We are interested in particular in the tactile information collected by the rodent whiskers and encoded in the barrel field of the primary somato-sensory cortex. Our work focuses on the coding of elementary stimuli at the scale of a single whisker and on the influence on this integration of the sensory context, which can be modulated e.g. by the spatio-temporal correlation of all whiskers.

To address these questions, our group develops new experimental tools that allow in two-photon fluorescence microscopy the optimal recording of neuronal network activity in vivo on anaesthetized or behaving animals: adaptive optics to improve imaging depth, ultrafast scans using acousto-optic deflectors to increase the temporal resolution of the recordings as well as their signal to noise ratio, and optical coherent tomography to visualize myelinated axons without labeling.

Membres de l'équipe

Wang Jinyu
Paresys Gérard
Léger Jean François
Ventalon Cathie