Behavior, Emotion and Basal Ganglia

Leader

Research center

47 bld de l'Hôpital
75651 Paris
Alexis Brice

Institution

Inserm
CNRS
Université Pierre et Marie Curie
ED158
Université Pierre et Marie Curie

Laboratory

SERBERA Marie-Catherine
Phone: 01 42 16 17 99 / 22 34
UMRS 1127 UMR 7225
IHU ICM

Mots clefs

Parkinson
Tourette
basal
ganglia
Depression
psychiatry
Experimental Psychology
refractory disease
OCD
translational medicine
Available to host a PhD student

publications

Morgiève M#, N'Diaye K#, Haynes WI#, Granger B, Clair AH#, Pelissolo A, Mallet L#. Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging. Psychol Med. 2014 May;44(7):1461-73.

Burbaud P#, Clair AH#, Langbour N, Fernandez-Vidal S#, Goillandeau M, Michelet T, Bardinet E#, Chéreau I, Durif F, Polosan M, Chabardès S, Fontaine D, Magnié-Mauro MN, Houeto JL, Bataille B, Millet B, Vérin M, Baup N, Krebs MO, Cornu P, Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J#, Welter ML, Mallet L#. Neuronal activity correlated with checking behaviour in thesubthalamic nucleus of OCD patients. Brain, 2013 Jan;136(Pt 1):304-17

Clair AH#, N'Diaye K#, Baroukh T, Pochon JB, Morgieve M#, Hantouche E, Falissard B, Pelissolo A, Mallet L#. Excessive checking for non-anxiogenic stimuli in obsessive-compulsive disorder. Eur Psychiatry 2012. 10.1016

Buot A#, Welter ML, Karachi C, Pochon JB, Bardinet E#, Yelnik J#, Mallet L#. Processing of emotional information in the human subthalamic nucleus. J Neurol Neurosurg Psychiatry 2012. 10.1136/jnnp-2011-302158

Palminteri S, Clair AH#, Mallet L#, Pessiglione M. Similar improvement of reward and punishment learning by serotonin reuptakeinhibitors in obsessive-compulsive disorder. Biol Psychiatry 2012; 72: 244-250.

Fields of research

Neurological and psychiatric diseases

Research Theme

The scientific core of our research program is to study the exact nature of the processing that the basal ganglia (BG) apply to cortical information with three perspectives: 1) improve our fundamental knowledge of the cerebral mechanisms of information processing; 2) better understand the pathophysiology of human diseases which are related to BG dysfunction; and 3) develop innovative treatments for neuropsychiatric refractory disorders notably by means of the deep brain stimulation (DBS) functional neurosurgery. This research is based on a confrontation between phenomenological and psychopathological studies of disturbances involving the BG and the electrophysiological, neuroimaging and anatomical studies of these structures.This research program is carried out in patients with Parkinson Disease, Tourette Syndrome, Obsessive Compulsive Disorder, Depression, Cocaine Dependence. Changes in the neuronal activity of BG and related cortical areas provoked by emotional or cognitive processing are examined by using dedicated experiments by means of electrophysiology and neuroimaging techniques. Precise anatomical localization of both electrophysiological and imaging data are performed using a validated 3D deformable atlas, allowing to model the circuits implicated and their interactions in these processes.

Membres de l'équipe

Jérôme Yelnick
Eric Burguière

Lab rotation

Optogenetic investigation of the striatal inhibitory network in compulsive behaviours

Chercheur responsable: 

MALLET Luc

Dates: 

2 January 2018 - 29 June 2018

Date limite de candidature: 

29 June 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

We propose to perform studies in mice in one of the main regulatory system of striatal activity: the parvalbumin (PV) interneuronal network. Recent studies in humans and animal models suggest that striatal interneurons could be pivotal in the emergence of repetitive behaviors. To causally test the implication of striatal PV-interneurons in the different types of repetitive behaviors, we propose to use an optogenetic strategy to manipulate interneurons activity and either induce or rescue repetitive behaviors in wildtype vs SAPAP3-KO mice, a mouse model of compulsive behaviours.

Contact

Institut du Cerveau et de la Moelle épinière - 47, boulevard de l’hôpital 75013 Paris - eric.burguiere@gmail.com

Superviseur: 

BURGUIERE Eric