Development and evolution of neurotransmission

Leader

Research center

Bâtiment 145, Centre d'études de Saclay
91191 Gif sur Yvette
Philippe Vernier

Institution

CNRS
Université Paris Sud
ED 568 BioSigNe
Université Paris Sud 11

Laboratory

Département Développement & Évolution du cerveau
Phone: 01 69 82 41 88
UMR9197
Idex NeuroSaclay

Mots clefs

Dopamine, hypothalamus, forebrain, neuronal plasticity, neurogenesis
Available to host a PhD student

publications

Yamamoto, K, Mirabeau, O., Bureau, C., Blin, M., Coudouel, S. and Vernier, P. (2013) Evolution of the dopamine receptor genes of the D1 class in Vertebrates. Mol. Biol. Evol. 30: 833-843

 Fontaine, R., Affaticati, P., Yamamoto, K, Jolly, C., Bureau, C, Baloche, S., Gonnet, F., Vernier, P., Dufour, S. and Pasqualini, C. (2013) Dopamine inhibits reproduction in zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Endocrinology 54: 807-18. doi: 10.1210/en.2012-1759.

Bosco A, Bureau C, Affaticati P, Gaspar P, Bally-Cuif L, Lillesaar C. (2013) Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. Development. 140: 372-84. doi: 10.1242/dev.089094.

Kalueff, AV, Stewart, AM, Kyzar, EJ, Cachat, J, Gebhardt, M., Landsman, S., Robinson, K, Maximino, C., Herculano, AM, Jesuthasan, S., Wisenden, B., Bally-Cuif, L., Lange, M., Vernier, P., Norton, W., Tierney, K., Tropepe, V., Neuhauss, SCF and the International Zebrafish Neuroscience Research Consortium. (2012) Time to recognize zebrafish ?affective? behaviour. Behaviour,149: 11019-1036

Razy-Krajka F, Brown, E., Horie, T., Callebert, J., Sasakura, Y, Joly, JS, Kusakabe, T and Vernier, P. (2012) Monoaminergic modulation of photoreception in ascidia: Evidence for a proto-hypothalamo-retinal territory. BMC Biol., 10: 45 doi:10.1186/1741-7007-10-45

Fields of research

Neurogenetics / neurodevelopment

Research Theme

Researches in the laboratory concern many fundamental aspects of brain development and evolution. The researches aim at better understand how the brains of different species develop during embryogenesis, how they are structured and organized as functional systems. Cellular and molecular mechanisms of morphogenesis (hypothalamus, thalamus and pallium, optic tectum) and differentiation (cholinergic and dopaminergic neurons) of the nervous system are compared in several model animals (ascidians, amphioxus, lampreys, zebrafish, medakafish, astyanax, Xenopus, chicken, and mice), in order to identify fundamental principles of neural development and differentiation. A special emphasis is given to the study of fundamental aspects of neural stem cells, including embryonic stem cells of the CNS and the neural crest. Implications for some human diseases are also studied.

Lab members have published more than 70 original papers and reviews during these last four years, many of them journals in journals with high impact factor. Researchers also actively participate in the dissemination of scientific information to public.

Lab rotation

Developmental plasticity of the telencephalic dopaminergic neurons in zebrafish

Chercheur responsable: 

VERNIER Philippe

Dates: 

1 September 2016 - 30 June 2017

Date limite de candidature: 

1 September 2016

Lab Rotation:

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

 The telencephalic dopaminergic neurons of the zebrafish brain are suspected to be the functional equivalent of the mesencephalic dopaminergic neurons, involved in the physiopathology of parkinson’s disease in humans. The project is to characterize the phenotype of these cells and its plasticity upon changes in neuronal activity. The project will allow the student to practice multiple methods combining histology/anatomy, electrophysiology and behavioral analysis in a stimulating scientific environment.

Address: Neuro-PSI Avenue de la terrasse - 91190 Gif-sur-Yvette

Phone: +33169824295 

Email: Michael.demarque@inaf.cnrs-gif.fr 

Website

Superviseur: 

Michaël DEMARQUE