Retinal information processing : pharmacology and pathologies

Leader

Research center

17 rue Moreau
75012 Paris
José-Alain Sahel

Institution

Inserm
Université Pierre et Marie Curie
CNRS

Laboratory

UMRS 968 - UMR 7210 - UM 80
Labex Lifesenses

Mots clefs

Vision
Retina
therapy
rehabilitation
blind
Available to host a PhD student

publications

Rosolen SG, Neveux N, Sahel J A, Picaud S. Froger N IntEvaluation of the taurine concentrations in dog plasma and aqueous humour: a pilot study. Adv Exp Med Biol. (2013) 775: 145-54.

Linderholm P, Guyomard JL, Djilas M, Salzmann J, Simonutti M, Sahel JA, Safran AB, Renaud P, Picaud S. Long-term in-vivo impedance changes of subretinal microelectrodes implanted in dystrophic P23H rats. International Journal of Artificial Organs (2013) DOI:10.5301/ijao.5000213.

Amel Bendali, Lucas H. Hess, Max Seifert, Valerie Forster, Anne-Fleur Stephan, Jose A. Garrido, Serge Picaud. Purified Neurons can Survive on Peptide-Free Graphene Layers. Adv. Health. Mater. (2013) 0.1002/adhm.201200347.

Lorach H., Benosman R., Marre O., Ieng S.H., Sahel J., Picaud S. Artificial retina : the multichannel processing of the mammalian retina achieved with a neuromorphic asynchronous light acquisition device. Journal of Neural Engineering (2012) 9(6):066004.

Froger N, Cadetti L, Lorach H, Martins J, Bemelmans A, Dubus E, Dégardin J, Pain D, Forster V, Chicaud L, Ivkovic I, Simonutti M, Fouquet S, Jammoul F, Léveillard T, Benosman R, Sahel J A, Picaud S. Taurine provides neuroprotection against retinal ganglion cell degeneration. Plos One (2012) 9(6):066004.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our lab studies the cellular and molecular mechanisms underlying retinal information processing. For instance, considering contrast enhancement at the photoreceptor terminals, which remains a matter of controversy, we have revisited the GABA hypothesis. Although this hypothesis first proposed in lower vertebrates was declined in the mammalian retina, we have demonstrated the presence of an unconventional GABAergic neurone and GABA receptor expression in cone photoreceptors. We also investigate how physiological mechanisms can interfere into pathological processes like the irreversible visual field constriction produced in epileptic patients by a blocker of the GABA degrading enzyme. We found that this first line drug for the treatment of infantile spasms or West syndrome, cause taurine deficiency leading to retinal phototoxicity. Recent studies have focussed on brain machine interfaces with artificial biological neuronal networks in vitro and retinal prostheses in vivo aiming at restoring vision in blind patients.



Lire le Dossier thématique "Rétine artificielle" réalisé en collaboration avec Serge Picaud et José-Alain Sahel, Institut de la vision (unité Inserm 968, Paris) et co-fondateurs de Pixium Vision – mai 2016. Certaines personnes qui ont perdu la vue suite à la dégénérescence de leurs cellules photoréceptrices peuvent désormais bénéficier d’une rétine artificielle. Fixé sur ou sous la rétine, cet implant leur permet de percevoir à nouveau des signaux lumineux. Plusieurs systèmes sont en cours d’évaluation, et la recherche se poursuit pour améliorer leurs performances et la perception visuelle des patients. Lire la suite - Source: Inserm. 

 

Lab rotation

Visual information processing : from normal function to visual restoration

Chercheur responsable: 

PICAUD Serge

Dates: 

1 September 2016 - 30 June 2017

Date limite de candidature: 

1 September 2016

Lab rotation proposal: 3 months 

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

In the team, we investigate visual function by multielectrode array techniques at the retinal and cortical level. These techniques are also used to validate prostheses and optogenetic therapy for restoring vision. New imaging techniques are also under development to achieve large population recordings. The lab rotation could contribute to these projects at different levels : recording, data analysis, modeling.

Address: Institut de la Vision - 17, rue Moreau 75012 Paris 

Phone number: +33 1 53 46 25 92 ; Mailserge.picaud@inserm.fr

Website

Superviseur: 

Serge PICAUD