Role of neuron-OPC synapses in myelination
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
Oligodendrocyte progenitor cells (OPCs) are a major glial cell population distributed throughout the developing and mature CNS. These cells express voltage-dependent ion channels, neurotransmitter receptors and establish functional synapses with neurons. An important question to address is whether these synapses between neurons and OPCs influences oligodendrocyte proliferation, differentiation and myelination during development.The goal of this project is to characterize, using in vivo two photon imaging, optogenetic and calcium imaging, the functional role of synapses between neurons and OPCs in the developing zebrafish spinal cord.
Address: ICM 47 bd de l’Hôpital, 75013 Paris