Molecular and cellular approaches of Myelin repair

Research center

47 bld de l'Hôpital
75651 Paris
Alexis Brice

Institution

Inserm
CNRS
Université Pierre et Marie Curie
ED158
Université Pierre et Marie Curie

Laboratory

Phone: 01 57 27 41 23 (41 24)
UMRS 1127 UMR 7225
IHU A-ICM, Neuratris

Mots clefs

myelin
myelination
repair
Multiple Sclerosis
Available to host a PhD student

publications

Moll NM, Hong E, Fauveau M, Naruse M, Kerninon C, Tepavcevic V, Klopstein A, Seilhean D, Chew LJ, Gallo V, Nait Oumesmar B (2013) SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis. Glia.

(10):1659-72.

Blanchard B, Heurtaux T, Garcia C, Moll NM, Caillava C, Grandbarbe L, Klosptein A, Kerninon C, Frah M, Coowar D, Baron-Van Evercooren A, Morga E, Heuschling P, Nait Oumesmar B (2013) Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis. J Neurosci. 33(28):11633-42.

Nakatani H, Martin E, Hassani H, Clavairoly A, Maire CL, Viadieu A, Kerninon C, Delmasure A, Frah M, Weber M, Nakafuku M, Zalc B, Thomas JL, Guillemot F, Nait-Oumesmar B, Parras C (2013) Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination. J Neurosci. 33(23):9752-68.

Tepavcevic V, Nait-Oumesmar B, Baron-Van Evercooren A. (2012) Olfactory dysfunction in multiple sclerosis: role for subventricular zone progenitors. Med Sci (Paris) 28(8-9):683-7.

Durrenberger PF, Fernando FS, Magliozzi R, Kashefi SN, Bonnert TP, Ferrer I, Seilhean D, Nait Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Parchi P, Capellari S, Arzberger T, Kretzschmar H, Roncaroli F, Dexter DT, Reynolds R (2012) Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study. Acta Neuropathol 124(6):893-903.

Fields of research

Neurological and psychiatric diseases

Research Theme

The team is based on two PIs, Anne Baron-Van Evercooren and Brahim Nait Oumesmar, who share a common interest in understanding how remyelination proceeds and how it can be promoted with a strong emphasis on remyelinating cells and animal models of demyelination. They have, however, their independent lines of investigations. Brahim Nait Oumesmar focuses on the transcriptional regulation of CNS myelination and remyelination and Anne Baron-Van Evercooren on cellular mechanisms of CNS remyelination with a special focus on stem cells and their role in the repair process. Our goal is dual: unravel some of the cellular mechanisms involved in the process of remyelination and develop strategies promoting myelin repair.

Etudiants ENP

Sabah MOZAFARI

Membres de l'équipe

DEBOUX Cyrille
KERNINON Christophe
MOISSONNIER Pierre
MOLL Natalia
SPIGONI Giulia
TEPAVCEVIC Vanja
THIBAUD Julie
TOUSSAINT Charline
VIDAL Marie
ZUJOVIC Violetta
BACHELIN Corinne
WEGENER Amélie

Lab rotation

Role of neuron-OPC synapses in myelination

Chercheur responsable: 

NAIT OUMESMAR Brahim

Dates: 

1 September 2016 - 30 June 2017

Date limite de candidature: 

1 September 2016

Lab Rotation:

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

Oligodendrocyte progenitor cells (OPCs) are a major glial cell population distributed throughout the developing and mature CNS. These cells express voltage-dependent ion channels, neurotransmitter receptors and establish functional synapses with neurons. An important question to address is whether these synapses between neurons and OPCs influences oligodendrocyte proliferation, differentiation and myelination during development.The goal of this project is to characterize, using in vivo two photon imaging, optogenetic and calcium imaging, the functional role of synapses between neurons and OPCs in the developing zebrafish spinal cord.

Address: ICM 47 bd de l’Hôpital, 75013 Paris

Email: brahim.nait_oumesmar@upmc.fr

Website

Superviseur: 

Brahim NAIT OUMESMAR & Anne BARON VAN EVERCOOREN