Investigating the role of astrocytic signaling in visual memory
Dates:2 April 2018 - 29 June 2018
Date limite de candidature:29 June 2018
There is accumulating evidence that implicates astrocyte in various aspects of physiopathology in the central nervous system. Based on recent literature, we hypothesize that activation of astrocytic signaling cascade in adult primary visual cortex (V1) triggers the release of (i) glutamate, (ii) pro-inflammatory molecules and/or (iii) synaptogenic, maturation or pruning factors to affect excitatory synaptic transmission, plasticity, cortical network activity and circuit formation. These would lead to the modulation of excitatory synaptic plasticity and visual memories. The rotation student will be involved in a project directly testing this hypothesis in vivo using the rodent V1 as well as novel powerful chemogenetic tools that we pioneered in astrocytes combined with, immunohistochemistry, biochemistry, electrophysiology, Ca2+ imaging, sensory behavior tests, and modeling.
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