Developmental mechanisms of brain disorders

Leader

Co-Leaders

Research center

17 rue du Fer à Moulin
75005 Paris

Institution

Inserm
Université Pierre et Marie Curie
Labex BIOPSY
ED158
Université Pierre et Marie Curie

Laboratory

Coutures Marianne
Phone: 33(0) 1 45 87 61 28
Fax: 33(0)145 87 61 35
UMRS 839

Mots clefs

migration
Cortex
Retina
serotonin
axon guidance
Neural activity
Critical periods
 

publications

Libé-Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, Métin C, Michalski N, Petit C. Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774.

Laclef C, Métin C. Conserved rules in embryonic development of cortical interneurons. Semin Cell Dev Biol. 2017 Sep 14. pii: S1084-9521(17)30241-0. 

Refining the Role of 5-HT in Postnatal Development of Brain Circuits.Teissier A, Soiza-Reilly M, Gaspar P. 2017 Front Cell Neurosci.23;11:139.

EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain. Teng T, Gaillard A, Muzerelle A, Gaspar P.2017 E-Neuro:.0327-16.

Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, Gaspar P. 2017 Neuropsychopharmacology;42(2):512-523.

 

Fields of research

Neurogenetics / neurodevelopment

Research Theme

A number of developmental disorders, in particular in the field of psychiatry and neurology, are thought to result from brain wiring defects. This is the case for mental retardation or autism-spectrum disorders, but also concerns non-cognitive pathologies such as visual defects in albinism. Formation of brain circuits is a complex process implying many sequential steps from the generation of neurons, their migration and axonal growth, and the establishment of selective synaptic connections. Refinement and consolidation of neural circuits continue during late periods of development, after birth, when the brain is the most plastic and likely to be modified by the environment with lasting effects on behaviour. Research in the team aims to understand the molecular mechanisms underlying the formation of brain circuits, along 3 main themes :

1° Migration of cortical interneurons : this theme is led by Christine Métin, focusing on the role of sonic hedgehog in cilia , using advanced live imaging methods.

2° Development of retinal visual pathways : this theme is led by Alexandra Rebsam focusing on the role of axon guidance molecules, neural activity and and neurotransmission in the establishment of visual maps. For more information, www.rebsam.org

3° Development of serotonin systems : this theme is led by Patricia Gaspar, focusing on the development of raphe and prefrontal cortical circuits influenced by serotonin and the effects of early life stress.



Etudiants ENP

Jimmy OLUSAKIN

Membres de l'équipe

Sophie SCOTTO
Aude MUZERELLE
Mariano SOIZA-REILLY
Anne TEISSIER
Cédric FRANCIUS
Teng TENG
Claire LECLECH
Maria PEDRAZA
Delphine PRIEUR
Alexandra REBSAM