Morphogenesis of the vertebrate brain

Research center

9 Quai Saint-Bernard Université Pierre et Marie Curie, Campus Jussieu, Bâtiments A-B-C
75005 Paris
Michel Labouesse

Institution

CNRS
Université Pierre et Marie Curie
ED158
Université Pierre et Marie Curie

Laboratory

Laboratoire de Biologie du Développement LBD
UMR 7622

Mots clefs

Morphogenèse du système nerveux, neurogénèse, cil primaire, signalisation, axone
Available to host a PhD student

publications

Chen C, Stedman A, Havis E, Anselme I, Onichtchouk D, Giudicelli F, Schneider-Maunoury S. Initiation of cyp26a1 Expression in the Zebrafish Anterior Neural Plate by a Novel Cis-Acting Element. PLoS One. 2016 Mar 9;11(3):e0150639. doi: 10.1371/journal.pone.0150639. eCollection 2016.

Breau MA, Schneider-Maunoury S. Cranial placodes: Models for exploring the multi-facets of cell adhesion in epithelial rearrangement, collective migration and neuronal movements. Dev Biol. 2014 Dec 23. pii: S0012-1606(14)00638-1. doi: 10.1016/j.ydbio.2014.12.012. 

Burcklé C., Gaudé H-M., Vesque C., Silbermann F., Salomon R., Jeanpierre C., Antignac C., Saunier S. and Schneider-Maunoury S. 2011. « Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros ». Human Molecular Genetics 20 :2611-2627. doi: 10.1093/hmg/ddr164.

Besse L., Neti M., Anselme I., Gerhardt C., Rüther U., Laclef C., and Schneider-Maunoury S. 2011. « Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing ». Development  138:2079-88.

Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S. 2009. A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Dev Biol. 327:566-77.

 Han YG, Spassky N, Romaguera-Ros M, Garcia-Verdugo JM, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A. 2008. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells.  Nat Neurosci. 11:277-84.

DelousM, BaalaL, SalomonR, Laclef C, VierkottenJ, ToryK, GolzioC, LacosteT, BesseL, OzilouC, MoutkineI, HellmanNE, AnselmeI, SilbermannF, Vesque C,(…) Schneider-Maunoury S, Attié-Bitach T and Saunier S.2007. The novel ciliary gene FTM is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nature Genetics, 39 p. 875-881. News and Views dans Nature Genetics, 39 p. 818-19.

Fields of research

Neurogenetics / neurodevelopment

Research Theme

Our group is interested in the molecular and cellular mechanisms underlying brain morphogenesis in vertebrates, and in understanding how these mechanisms are perturbed in human diseases.

To investigate these processes, we take advantage of two complementary model organisms, the mouse and the zebrafish. We have three main research axes.

1) We study the gene regulatory hierarchies involved in the early subdivision of the neural plate, the future central nervous system, during gastrulation.

2) We investigate the function of primary cilia in brain morphogenesis. Specifically, we study the Rpgrip1L gene, which codes for a protein localized at the ciliary transition zone and whose mutations have been identified in two human ciliopathies, Joubert and Meckel syndromes.

3) We have demonstrated the presence of axonal transport of mRNAs in zebrafish embryos and we currently study its mechanisms and functions

Membres de l'équipe

VESQUE Christine
LACLEF Christine
ANSELME Isabelle