SCaNR : Stem Cells and Neurogenesis in the Retina

Leader

Research center

Bâtiment 145, Centre d'études de Saclay
91191 Gif sur Yvette
Philippe Vernier

Institution

CNRS
ED 568 BioSigNe
Université Paris Sud 11

Laboratory

Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)
UMR9197
Idex NeuroSaclay

Mots clefs

Neural stem cells
Retina
Proliferation
regeneration
Signaling pathways
Available to host a PhD student

publications

 

Langhe R, Chesneau A, Colozza G, Hidalgo M, Locker M and Perron M (2017). Müller glial cell reactivation in Xenopus models of retinal degeneration. Glia, 65(8):1333-1349. Hamon A, Masson C, Bitard J, Gieser L, Roger JE, and Perron M (2017). Retinal degeneration triggers the activation of YAP/TEAD in reactive Müller cells. IOVS, 58(4):1941-1953.

Schietroma C*, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel J-A, Perron M, El-Amraoui and Petit C. (2017). Shaping of the photoreceptor outer segment by the calyceal processes of the inner segment. Journal of Cell Biology, 216(6):1849-1864.

Pfirrmann T, Jandt E, Ranft S*, Lokapally A, Neuhaus H, Perron M, Hollemann T. (2016). Hh-dependent E3-Ligase Mid1 leads to ubiquitin-mediated proteasomal degradation of Pax6 protein from the forming optic stalk. PNAS 113(36):10103-8.

Cabochette P, Vega-Lopez G, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O, Perron M (2015). YAP controls retinal stem cell DNA replication timing and genomic stability. eLife 4:e08488.

Fields of research

Neurogenetics / neurodevelopment

Research Theme

Our research program focuses on neural stem cells in both mice and Xenopus retina. The amphibian retina contains a population ofneural stem cells, which, in contrast to the mammalian situation, are active, allowing continuous tissue growth throughout the animallife, as well as regeneration following retinal damage.

Using this first model, our team is investigating how signalling pathways andintrinsic factors work in concert to finely regulate the balance between quiescence, proliferation and differentiation in physiological andneurodegenerative conditions. In addition, the laboratory of Retina France association (the CERTO) has joined our research group since December 2012. Together, we are now also developing researches in murine models of neurodegenerative diseases.

Our goal is to uncover molecular cues that could awake the neurogenic potential of dormant mammalian retinal stem cells and therebystimulate regeneration, an approach that should contribute to the elaboration of stem-cell-based therapeutic strategies to treat retinaldystrophies.

 



Membres de l'équipe

Laurent Théodore
Odile Bronchain
Morgane Locker
Christel Masson-Garcia
Jérôme Roger
Karine Parain
Albert Chesneau
Juliette Bitard
Elodie Grellier
Rahul Langhe
Divya Ail
Elena Braginskaja
Annaïg Hamon
Suma Medisetti
Anaïs Laine