Multisensory signal processing: From whole-brain activity to behavior

Leader

Research center

4 place Jussieu Tour 32
75005 Paris
Didier Chatenay

Institution

Université Pierre et Marie Curie
CNRS
ED 564
UPMC

Laboratory

Bormuth
Phone: (+33) 1 44 27 46 89
UMR 8237

Mots clefs

light-sheet microscopy
zebrafish
multisensory signal processing
whole-brain calcium imaging
Available to host a PhD student

publications

 Seclected Publications:

1. Bormuth, V., Barral, J., Joanny, J.F., Jülicher, F. & Martin, P.     Transduction channels gating controls friction on vibrating hair-cell bundles in the ear.

PNAS 111, 7185-90 (2014)

2. Gardner, M.K.*, Zanic, M.*, Gell, C., Bormuth, V., & Howard J.     Depolymerizing Kinesins Kip3 and MCAK Shape Cellular Microtubule Architecture by Differential Control of Catastrophe.

CELL 147, 1092-1103 (2011)  

3. Bormuth, V., Varga, V., Howard, J., & Schäffer, E.     Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

SCIENCE 325, 870 - 873 (2009)  

4. Varga, V.*, Leduc, C.*, Bormuth, V., Diez, S., & Howard, J.     Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization.

CELL 138, 1174-83 (2009)  

5. Bormuth, V.*, Otsu, Y.*, et al.     Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope.

J. Neurosci. Methods 173(2), 259-270 (2008)    

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherentrepresentation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and isimplicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensoryprocessing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while thesmallest operational units are single multisensory neurons.

In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activityof brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain ofzebrafish larvae as a model system. We focus on gaze stabilization as an inherently multisensory model task that is conservedamong all vertebrates. This reflex uses both vestibular and visual information to drive eye movements in order to compensate forself-motion and maintain clear vision. We have developed a novel experimental platform in which a restrained larva can be submittedto vestibular and visual stimuli, as a pilot in a flight simulator. We can optically record the activity of all 100,000 neurons of the animalbrain as it performs multisensory integration tasks.To extract basic principles of how behavior is coded in multisensory neuronal circuits we interpret the brain-wide activity and theobserved behavior with methods from statistical physics. No other system can today provide a similar brain-scale, yet cell-resolvedview on the neuronal network dynamics subserving such a complex integration process.

We use this system to address three fundamental and generic questions relevant to multi-sensory integration.

1 – Multi-sensory enhancement. How multi-modal congruent sensory cues are integrated at the circuit level to enhance the precisionof the evoked motor response?

2 – Decision-making: Resolving conflicting sensory cues. When the brain is submitted to conflicting stimuli, which neuronalmechanism controls the prioritization of one sensory cue over the other?

3 – Cross-modal adaptation. How constantly out-of-register stimuli induces network plasticity in order to recover a coherentrepresentation ?

PostDoc position opening

Desired skills: Strong background in neuroscience or biophysics; matlab-based image and signal processing; labview programming; neuronal circuit modeling; electrophysiology; zebrafish genetics; motivation. How to apply: Applications will comprise the names of three references, an application letter, a CV and a publications list including preprints. Informal inquiries are welcome. 

Membres de l'équipe

Thomas Panier (PostDoc)
Kris Severi (PostDoc)
Geoffrey Migault (PhD)
Hugo Trentenseaux (PhD)
Matthieu Dujany (Master)
Louis Chevalier (Master)

Lab rotation

Multisensory signal processing in larval zebrafish

Chercheur responsable: 

BORMUTH Volker

Dates: 

18 September 2017 - 29 June 2018

Date limite de candidature: 

29 June 2018

Period

~ Sept-Dec 2017

~ Jan-March 2018

~ April-June 2018

Project

In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activity of brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain of zebrafish larvae as a model system. We developed a novel experimental platform in which a restrained larva can be submitted to vestibular and visual stimuli, as a pilot in a flight simulator. However, in the case of the larva we can optically record the activity of all 100,000 neurons of the animal brain as it performs multisensory integration tasks. We propose lab rotation projects in the following domains: behavioral experiments, whole-brain functional calcium imaging and data analysis. 

Contact

Laboratoire Jean Perrin - 4, place Jussieu 75005 Paris - +33 1 44 27 20 06 - Volker.bormuth@upmc.fr

Superviseur: 

BORMUTH Volker