Pathological spreading of patient-derived Synuclein fibrils in mouse
Dates:18 September 2017 - 29 June 2018
Date limite de candidature:29 June 2018
~ Sept-Dec 2017
~ Jan-March 2018
~ April-June 2018
Our working hypothesis is that alpha-synuclein (SYN) assemblies with different structural characteristics or ‘strains’ display distinct spreading, tropism, clearance and neurotoxicity. The goal of the project is to test in vivo (mouse) the pathological spreading capacity of different fibrillary SYN assemblies obtained by protein misfolding cyclic amplification (PMCA) of patient-derived brain aggregates (PD, MSA, DLB). Technics such as stereotaxic brain injections, immunohistochemistry and image analysis will be employed.
Institut du Cerveau et de la Moelle épinière - 47, boulevard de l'Hôpital 75013 Paris - +33 1 57 27 45 56 - Stephane.firstname.lastname@example.org