Maria Cecilia ANGULO
Directeur de recherche


Oligodendrocyte precursor cells expressing the chondroitin sulfate proteoglycan NG2, also called NG2 cells, have the ability to proliferate in the postnatal brain to generate oligodendrocytes in grey...

Biographie / Publications


[From 2011] Research Director at CNRS (DR2), France. Team leader of the group "Physiology of NG2 cells" in Laboratory of Neurophysiology and New Microscopies, INSERM U603, CNRS UMR8154, Univ. Paris Descartes, Paris (France).

[2002-2010] Research scientist at CNRS (CR2 and CR1) in the same laboratory



[2000-2001] Postdoctoral training; Dpto of Experimental Biomedical Science; Padova, Italy

[1996-1999] PhD Thesis; Univ. Pierre and Marie Curie and Lab. of Neurobiology, ESPCI, CNRS UMR7637, Paris, France.

[1995-1996] Advanced studies diploma (DEA) ; Univ. Pierre et Marie Curie, Lab. of Neurobiology, ESPCI, CNRS UMR 7637, Paris, France.


Fellowships and Awards:

[2005-2007] Young investigator award from ?National Alliance for Research on Schizophrenia and Depression? (NARSAD), USA (60000 USD for research).

[2000-2001] HFSPO postdoctoral fellowship.

[1999] Best PhD thesis award from Société de Neurosciences française (SNF).

[1999] PhD fellowship from Fondation pour la recherche Médicale (FRM) (France).

Recent Invited conferences:

[2013] Seminar, Department of neurogenetics, Max-Planck-Institute of Experimental Medicine, Gottingen (May 29, 2013).

[2013] 11e Colloque de la Société des Neurosciences, Symposium: FRC, Lyon (21-24 mai).

[2012] The Myelin Gordon Research Conference, Il Ciocco (April 29 to May 4).

[2012] Second franco-argentinian symposium of Neurosciences, Buenos Aires (April 9-12).

[2011] 10th European meeting of glial cells in health and disease, Prague (September 13-17; symposium organizer and speaker:

Functional roles of channels, receptors and synapses of NG2 cells).

[2010] Summer meeting of the Anatomical Society (UK). Axonal?glia interactions in the CNS. Portsmouth, UK (July 20-22).

[2009] 9th European meeting of glial cells in health and disease, Paris (September 8-12; satellite meeting: ?application of imaging

techniques for understanding glial functions in the nervous system?).


Present national and international collaborations:

Brahim Nait Oumesmar (ICM, University Pierre and Marie Curie, Paris, France)

Alessandra Pierani (Institut Jacques Monod, Paris, France)

Gerald Seifert (University of Bonn, Bonn, Germany)

R. Douglas Fields (NIH, Bethesda, USA)



[2004-present] Neuron-glia interactions. Master 1: Biology, section Neurosciences, Ecole Normale Supérieure (ENS).

[2006-2008] The role of glial cells in neuro-vascular coupling. Master 2: Physiology and integrative biology. Université Pierre et Marie

Curie(Paris VI), Paris.

[2007-present] Neuron-glia interactions; Master 2: Neurobiology, Université Paris Descartes (Paris V), Paris.

[2009-present] Physiology of NG2 cells. Master 2: Physiology and integrative biology, University Pierre and Marie Curie (Paris VI).


Selected publications

1. Maldonado PP, Vélez-Fort M, Levavasseur F, Angulo MC (2013) Oligodendrocyte precursor cells are accurate sensors of local K+

in mature gray matter. Journal of Neuroscience 33(6):2432-42

2. Vélez-Fort M, Maldonado PP, Butt AM, Audinat E, Angulo MC (2010) Postnatal switch from synaptic to extrasynaptic transmission

between interneurons and NG2 cells. Journal of Neuroscience 30(20):6921-9

3. Vélez-Fort M, Audinat E, Angulo MC (2009) Functional ?7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. Glia 57:1104-14

4. Zahid M*, Vélez-Fort M*, Papagiakoumou E, Ventalon C, Angulo MC, Emiliani, V (2010) Holographic photolysis to stimulate

multiple cells in brain slices. PLoS One 5(2) :e9431

*Co-first authors

5. Zonta M.*, Angulo M.C.*, Gobbo S., Rosengarten B., Hossmann K.A., Pozzan T., Carmignoto G. (2003) Neuron-to-astrocyte

signaling is central to the dynamic control of brain microcirculation. Nature Neuroscience. 6(1):43-50. *Co-first authors