During her PhD, Keerthana investigated the molecular basis of the formation and specificity of two synapses formed on the same target neuron using the olivo-cerebellar network as a model system. With a particular focus on proteins related to the complement system, she contributed to a study demonstrating that different members of the C1Q family are important determinants of the identity and specific connectivity of the two excitatory synapses formed on cerebellar Purkinje cells.
Sigoillot SM, Iyer K, Binda F, Calvo IG, Talleur M, Vodjdani G, Isope P, Selimi F. The C1QL1 secreted protein and its receptor, the adhesion-GPCR BAI3, control the synaptic connectivity of convergent excitatory inputs on cerebellar Purkinje cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] Pubmed PMID: 25660030
Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. Pubmed PMID: 23628982