Does RdCVF metabolic signaling stimulate outer segment regrowth
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
Lab rotation proposal:
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
In patients suffering from retinitis pigmentosa (RP), the most prevalent form of inherited retinal disease leading to untreatable blindness, cone outer segments are shortened with the progression of the disease, although cones survive even in advanced cases of RP. The mode of action of Rod-derived Cone Viability Factor (RdCVF) as revealed recently [Aït-Ali et al. Cell. 2015 May 7;161(4):817-32] implies that the administration of RdCVF in RP patients could not only stabilize their central vision but also restore vision by stimulating cone outer segments re-growth. The student will work on a mouse model we have developed to establish a proof of concept using gene therapy of this medically relevant phenomenon.
Address: Institut de la Vision - 17, rue Moreau 75012 PARIS
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