Targeting chloride homeostasis in temporal lobe epilepsies
Dates:18 September 2017 - 29 June 2018
Date limite de candidature:29 June 2018
~ Sept-Dec 2017
~ Jan-March 2018
~ April-June 2018 (to be discussed)
Temporal lobe epilepsy (TLE) is among the most common forms of complex partial epilepsy and represents about 60% of all epileptic patients. It is often resistant to common antiepileptic drugs and TLE patients may then have no other option than surgical therapy, calling for identification of new therapeutically relevant target.
Our research aims at better understanding the molecular and cellular mechanisms underlying epileptogenesis and we currently focus on deficits in chloride transport that may represent new therapeutic targets in TLE. In this project, we will evaluate the efficacy of various drugs targeting chloride transport on the emergence of epileptiform activities. To this end, we will use multi-electrode array (MEA) recordings of network activity from human brain tissue resected from epileptic patients.
In parallel, in vivo electrophysiological recordings from mouse models will be used to manipulate chloride transporter expression using viral transduction. These experiments will let us test whether altered chloride transporter expression may be causal to TLE and whether drugs targeting these transporters may be beneficial to rescue network activity in TLE patients.
Basic knowledge in electrophysiology would be an asset but is not strictly.
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