Neural Processing, Neuromodulation and sensory plasticity


Research center

1 avenue de la Terrasse1 avenue de la Terrasse
91190 Gif-sur-Yvette
Yves Frégnac


Université Paris Sud
ED158 - 3C ED FDV
Université Pierre et Marie Curie


Phone: 01 69 82 34 00
Idex NeuroSaclay - Equipe FRM
Available to host a PhD student


Estebanez, L.#, Bertherat, J.#, Shulz, D.E.#, Bourdieu, L. and Léger, J. F. (2016) A radial map of multi-whisker correlation selectivity in the rat barrel cortex. Nature Communications DOI: 10.1038/ncomms13528

Perronnet L#, Vilarchao ME#, Hucher G, Shulz DE#, Peyré G, Ferezou I.#(2015) An automated workflow for the anatomo-functional mapping of the barrel cortex J Neurosci Methods doi:10.1016/j.jneumeth.2015.09.008.

Boubenec, Y.#, Claverie, N., Shulz, D.E.# and Debregeas, G. (2014) An amplitude modulation/demodulation scheme for whisker-based texture perception. J. Neuroscience, 34:10832–10843.

Arduin P-J.#, Frégnac Y., Shulz D.E.# & Ego-Stengel V.# (2014) Bidirectional control of a one-dimensional robotic actuator by operant conditioning of a single unit in rat motor cortex. Frontiers in Neuroscience (Neuroprosthetics) Vol. 8/206 : 1-15.

Arduin, P.J.#, Frégnac, Y., Shulz, D.E.# and Ego-Stengel, V.#, (2013). "Master" neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. J. Neuroscience. 33:8308–8320.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The Team is specialized in integrative neuroscience. Using the barrel cortex of rodents as a system model, our research is centered on the study of neuronal processes responsible for the coding of tactile sensory information and perception, as well as their regulation through the interaction of the animal with the environment. We are interested in the propagation and integration of neuronal information in the primary somatosensory cortex and subcortical somatosensory relays, and the emergence of collective properties in response to spatially distributed stimuli on the receptor surface. In addition, we study the functional and synaptic adaptation within the framework of Hebbian and non-Hebbian plasticity algorithms. We include in this research the study of permissive factors linked to the attentional and behavioral state of the animal which are mediated by ascending neuromodulatory systems. Our research involves a combination of cutting edge techniques (multi-electrode electrophysiology, functional imaging (VSD), optogenetics, multiple-whisker stimulation, behaviour) in acute and chronically implanted preparations.