Cellular pathology of a neurodegenerative disease
Dates:1 September 2016 - 31 December 2016
Date limite de candidature:1 September 2016
Lab rotation proposal:
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
Neuronal ceroid lipofuscinoses (NCLs) are a group of rare neurodegenerative disorders characterized by blindness, epileptic seizures, motor deterioration, and dementia. We aim to investigate the hypothesis that lysosomal proteolysis is a convergent defect of NCLs using metabolomic, biochemical and cell biological approaches on cellular and mouse models.
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