Imagerie et Psychiatrie

Research center

4, place du Général Leclerc
91401 Orsay

Institution

Inserm
CEA
ED158
Université Paris Saclay / Université Paris Descartes

Laboratory

Laboratoire Imagerie et Psychiatrie
U1000
IHU Necker

Mots clefs

Depression
autisme
Schizophrénie
Imagerie du cerveau
addictions
Available to host a PhD student

publications

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192

 

Fields of research

Neurological and psychiatric diseases

Research Theme

Cerebral development, imaging and psychopathology

The first axis of research is to characterize psychiatric disorders linked to brain development, using anatomical and functional neuroimaging. Patient groups with psychiatric disorders beginning in the early decades of life, are studied at complimentary periods: childhood, adolescence, adulthood.

Searching for anatomical and functional changes of the brain in a few selected psychiatric syndromes. Autism, schizophrenia and addiction are examples of psychiatric conditions for research in neuroimaging. The comparison with addiction disorders provides a thorough characterization of the detected variations.

Neuroimaging and psychiatrics treatments

The second research axis is to identify the brain sites of action of psychotropic drugs and monitoring treatment effects.

We search for relationship between response to treatment and anatomical or functional brain specificities.

Three imaging techniques were adapted to explore the brain of subjects with various mental disorders:
• 1 / MRI (Magnetic Resonance Imaging) for brain morphology,
• 2 / functional MRI (fMRI)for brain function,
• 3 / PET (Positron Emission Tomography) for neurochemistry.

The researches of the Unit 1000  INSERM-CEA are performed on CEA platforms, Service Hospitalier Frédéric Joliot and Neurospin. The unit includes two sub-sites, one in the department of Paediatric Radiology of theNeckerHospital, the other one in the Solenn House, adolescents' house,CochinHospital.