Role of striatal interneurons in goal directed behavior
Dates:18 September 2017 - 29 June 2018
Date limite de candidature:29 June 2018
~ Sept-Dec 2017
~ Jan-March 2018
~ April-June 2018
Basal ganglia are involved in goal-directed behavior and procedural learning. Striatum, the main input nucleus of basal ganglia, is composed of a majority of striatal projection neurons, but also of a variety of GABAergic interneurons which, and exert a strong feedforward inhibition. As we recently showed, GABAergic interneurons efficiently control synaptic hebbian plasticity (Paille et al., 2013, J Neurosci; Valtcheva et al., 2017, Neuropharmacol; Valtcheva and Venance, 2017, Nat Comm).
In this project we aim at optogenetically activating or inhibiting specifically each GABAergic subpopulation in dorsal striatum and observe the impact on a goal directed task and the associated procedural learning and recall. Neuronal activity in the behaving mice will be concomitantly examined with multi-channels recordings.
Techniques: in vivo optogenetics, behavioral tasks, in vivo multi-channel recordings, immunohistochemistry.
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