Mechanisms of non-invasive brain stimulation for neural circuit repair
Dates:18 September 2017 - 29 June 2018
Date limite de candidature:29 June 2018
~ Sept-Dec 2017
~ Jan-March 2018
~ April-June 2018 (to be discussed)
Non-invasive brain stimulation such as by repetitive magnetic stimulation (rMS) can modify neural circuit function and shows promise in treating a range of neurological disorders including injury and stroke. Our team has recently shown that a low intensity rMS, which is below depolarization threshold, can improve complex learned and reflex behaviors by removing abnormal ectopic neural connections, altering neuronal morphology (spines and dendritic branching) and modifying gene expression. We are interested in how this non-depolarizing rMS induces such profound effects: what intracellular signaling paths (eg calcium) are changed? Does the brain contain magnetoreceptors? The project will use an in vitro organotypic model of axonal injury to identify molecular mechanisms underlying different rMS protocols, including the requirement for potential magnetoreceptors.
Institut de Biologie Paris Seine - Bat B 4th floor, 9 Quai St Bernard 75005 Paris - +33 1 44 27 33 78 ; +33 1 44 27 32 40 - Rachel.firstname.lastname@example.org