Développement et Neuropharmacologie


Research center

11 place Marcelin Berthelot
75231 Paris
Alain Prochiantz


Collège de France
Université Pierre et Marie Curie


Center for Interdisciplinary Research in Biology
Phone: +33 1 44 27 15 56
UMR 7241 - U 1050
Available to host a PhD student


F.-X. Blaudin de Thé (co-first), H. Rekaik (co-first), E. Peze-Heidsieck, O. Massiani-Beaudoin, R.L. Joshi, J. Fuchs* & A. Prochiantz, 2017. LINE-1 repression attenuates degeneration in adult dopaminergic neurons. BioArchives.

H. Rekaik (co-first), F.-X. Blaudin de Thé (co-first), J. Fuchs, O. Massiani-Beaudoin, A. Prochiantz* & R. Joshi (2015). Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress. Cell Reports, 13, 1-9

C. Bernard (co-first), C. Vincent co-first) D. Testa (co-first), E. Bertini, J. Ribot, A.A. Di Nardo, M. Volovitch & A. Prochiantz (2016). A mouse model for conditional secretion of specific single-chai antibodies provides genetic evidence for regulation of cortical plasticity by a non-cell autonomous homeoprotein transcription factor. PLOS Genetics, DOI:10.1371.

H.H.C. Lee (co-first), C. Bernard (co-first), Z.Y. MA, D. Acampora, A. Simeone, A. Prochiantz, A.A. DI Nardo* & T.K. Hensch* (2017). Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol. Psy., 22, 680-688, 2017.

J. Apulei (co-first), N. Kim (co-first), D.Testa (co-first), J. ribot, C. Bernrad, A.A. Di Nardo* & A. Prochiantz (2017). Non-cell autonomus Otx2 homeoprotein regulates visual cortex plasticity through GADD45b. BioArchives.

Research Theme

Our research is centered on the physiological function of homeoprotein intercellular transfer, a novel signaling mechanism discovered by our group and that of Alain Joliot, also a CIRB member. This research has basic and translational aspects.