Développement et Neuropharmacologie

Leader

Research center

11 place Marcelin Berthelot
75231 Paris
Alain Prochiantz

Institution

Collège de France
CNRS
Inserm
ED158
Université Pierre et Marie Curie

Laboratory

Center for Interdisciplinary Research in Biology
Phone: +33 1 44 27 15 56
UMR 7241 - U 1050
Available to host a PhD student

publications

F.-X. Blaudin de Thé (co-first), H. Rekaik (co-first), E. Peze-Heidsieck, O. Massiani-Beaudoin, R.L. Joshi, J. Fuchs* & A. Prochiantz, 2017. LINE-1 repression attenuates degeneration in adult dopaminergic neurons. BioArchives.

H. Rekaik (co-first), F.-X. Blaudin de Thé (co-first), J. Fuchs, O. Massiani-Beaudoin, A. Prochiantz* & R. Joshi (2015). Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress. Cell Reports, 13, 1-9

C. Bernard (co-first), C. Vincent co-first) D. Testa (co-first), E. Bertini, J. Ribot, A.A. Di Nardo, M. Volovitch & A. Prochiantz (2016). A mouse model for conditional secretion of specific single-chai antibodies provides genetic evidence for regulation of cortical plasticity by a non-cell autonomous homeoprotein transcription factor. PLOS Genetics, DOI:10.1371.

H.H.C. Lee (co-first), C. Bernard (co-first), Z.Y. MA, D. Acampora, A. Simeone, A. Prochiantz, A.A. DI Nardo* & T.K. Hensch* (2017). Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol. Psy., 22, 680-688, 2017.

J. Apulei (co-first), N. Kim (co-first), D.Testa (co-first), J. ribot, C. Bernrad, A.A. Di Nardo* & A. Prochiantz (2017). Non-cell autonomus Otx2 homeoprotein regulates visual cortex plasticity through GADD45b. BioArchives.

Research Theme

Our research is centered on the physiological function of homeoprotein intercellular transfer, a novel signaling mechanism discovered by our group and that of Alain Joliot, also a CIRB member. This research has basic and translational aspects.

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