From circuit to dendritic activities in active cortical slices in vitro
Dates:2 January 2018 - 29 June 2018
Date limite de candidature:29 June 2018
~ Jan-March 2018
~ April-June 2018
We use refined techniques to maintain spontaneous slow oscillations (up and down states) in preserved neural circuits in mouse brain slices, and explore dendritic dynamics in individual neurons using voltage sensitive dye imaging.In a recently designed slice, both the entorhinal cortex and the claustrum (a mysterious structure hypothetized as a hub for attention and consciousness, linking most cortical areas in the brain. Goll et al., TINS 2015) are both strongly synaptically active. The project will explore interactions between these structures and their cell/circuits dynamics using patch-clamp and calcium and voltage imaging.
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