ENP alumna Emma Cahill, now a postdoc at Cambridge University, studied the interactions of dopamine and glutamate signaling in response to cocaine during her PhD. She also contributed to an insightful publication on Huntington’s disease and signaling in the striatum. The neurodegeneration in Huntington’s disease is characterized by accumulation of mutated Huntingtin protein, impaired mitochondria function, axonal transport and transcription, among other deficits. Find more information about these mechanisms in the article:
Roze E, Cahill E, Martin E, Bonnet C, Vanhoutte P, Betuing S, Caboche J. Huntington’s disease and striatal signaling. Front Neuroanat. 23 August 2011.
Key words: Polyglutamine, Huntingtin, Excitotoxicity, Mitochondrial dysfunctions, Transcriptional deregulation
Figure 1 from Roze et al., Front Neuroanat, 2011. Afferent projections onto the striatum, whose signaling is impaired in Huntington's disease.