Research Highlight: WNTs in Zebrafish

ENP team leader Sylvie Schneider-Maunoury and her group have advanced our understanding of Wnt pathways in zebrafish morphogenesis. They found that a ciliary protein nephrocystin-4 is required for extension of the caudal pronephric primordium, that it controls the organization of cells in the formation of the cloaca, that it regulates the stability and localization of dishevelled, and that it represses the Wnt-β-catenin pathway. Check out the article for more information:

Burcklé C, Gaudé HM, Vesque C, Silbermann F, Salomon R, Jeanpierre C, Antignac C, Saunier S, Schneider-Maunoury S. Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum Mol Genet. 1 July 2011. 20(13): 2611-2617.

Key words: Nephrocystin-4 Inversin Zebrafish Wnt