Research Highlight: Macular Degeneration

ENP team leader Serge Picaud and his group have recently investigatedthe role of light in the development of age-related macular degeneration(ARMD). Blue light was found in epidemiological studies to accelerate the development of this major retinal disease. Therefore, a cell model was used to define the most toxic wavelengths in blue light normalized to the sun light irradiance reaching the retina. This project required the development of an original light stimulation device allowing exposition to 10nm light bands. Surprisingly, the team observed that the highest toxicity is neither generated by the highest irradiances nor by the highest energy photons but by a band between 415 and 455nm. This project opens the way to the production of specific optic filters for ARMD patients.  

Check out the article for more information:

Arnault E, Barrau C, Nanteau C, Gondouin P, Bigot K, Vienot F, Gutman E, Fontaine V, Villette T, Cohen-Tannoudji D, Sahel JA, Picaud S. Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions. PLoS One. 23 August 2013. 8(8): e71398.

Key words: Retina Macular degeneration Sun damage Blue light Phototoxic spectrum

Figure 2 from Arnault et al., PLoS One, 2013.