Research Highlight: Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex
By using dense multi-electrode recordings in human and monkey, together with computational modeling, ENP scientist Alain Destexhe and his team, show that the excitatory and inhibitory neuron activities are tightly following each-other and co-fluctuate. This balance is seen in wakefulness and in all sleep states, and breaks down only during epileptic seizures.
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Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex. Nima Dehghani, Adrien Peyrache, Bartosz Telenczuk, Michel Le Van Quyen, Eric Halgren, Sydney S. Cash, Nicholas G. Hatsopoulos & Alain Destexhe
Figure: Balanced activity in sample recordings of awake (A), slow-wave sleep (SWS) (B) and rapid-eye movement (REM) sleep (C) in human. Putative inhibitory neurons (FS cells) are shown in red, while putative excitatory neurons (RS cells) are depicted in blue. The rasters of RS and FS cells are shown with the corresponding LFP trace (on top, blue), and the histograms (bottom) show the overall activity of RS (blue) and FS (red) cell populations.