Research Highlight: Conditional influence of an antidepressant drug on subdivisions within the amygdala

ENP team leader Therese Jay and colleague Bill Godsil recently published a new article in the journal Molecular Psychiatry. They found evidence that the antidepressant drug tianeptine can have a conditional influence on the activation of specific subdivisions of the central nucleus of the amygdala, whereby the drug’s influence depends on ongoing activation in the connected network. They also found that a dose of tianeptine can impede a rat’s ability to learn to inhibit its fear during a behavioral extinction procedure, which suggests that tianeptine could impede progress during human exposure-based therapy for anxiety disorders. 

Check out the article for more information:

Godsil BP, Bontempi B, Mailliet F, Delagrange P, Spedding M, Jay TM (2015) Acute tianeptine treatment selectively modulates neuronal activation in the central nucleus of the amygdala and attenuates fear extinction. Mol Psychiatry. doi: 10.1038/mp.2014.169. 

Keywords: Tianeptine, Corticolimbic network, Fear extinction