His research, which includes both clinical and basic research, aims at elucidating the molecular basis and physiopathological mechanisms of several hereditary neurodegenerative disorders including Parkinson’s disease, frontotemporal lobar degeneration, cerebellar ataxia and spastic paraplegia. He received awards from the Academy of Science (Institut de France: Prix François Lhermitte for research on Parkinson's Disease in 2005), from the Academy of Science (Institut de France: Grand Prix Lamonica de Neurologie in 2011) and the Prize of the Roger de Spoelberch Foundation in 2012.
From 2001 to 2009, Alexis Brice has been the Head of the Department of Genetics at the Pitié-Salpêtrière University Hospital associated with the University Pierre and Marie Curie (Paris 6) medical school. He is also the coordinator of the National Reference Centre for Neurogenetics. He is director of the ICM (Brain and Spine Institute) and heads a research group doing research on Neurogenetics and the DNA and Cell Bank at the Inserm Unit UMR_S1127, associating the CNRS, INSERM and the University Pierre and Marie Curie at the Pitié-Salpêtrière Hospital.
A graduate of the Necker-Enfants-Malades of Paris medical school, he received his neurological training in Paris before being appointed associate professor of Cell Biology then professor of Genetics at the University Pierre and Marie Curie.
He has held positions in a variety of national and international scientific boards including the Wellcome Trust and was vice-president of the Inserm Avenir Program, and is a member of the editorial board of several journals in the fields of Genetics and Neurology. He also was Chairman of the Institute for Neuroscience, Neurology and Psychiatry in Paris.