Aijaz Parray, an alumnus of the ENP graduate program, contributed to an important finding on the organization of the retina. He and his teammates used a mouse model to study stratification of the layers of the retina. They discovered that the transmembrane semaphorin Sema6A targets its receptor PlexA4 to control lamina-specific neuronal stratification. For more details, see the article:
Matsuoka RL, Nguygen-Ba-Charvet KT, Parray A, Badea TC, Chédotal A, Kolodkin AL. Transmembrane semaphorin signaling controls laminar stratification in the mammalian retina. Nature. 2011. 470: 259-263.
Figure 1a and b from Matsuoka et al., Nature, 2011. Immunostained sections of adult retina in wild-type and PlexinA4 null mice. Immunohistochemistry conducted against tyrosine hydroxylase in these images