September 2012
28 September 2017

Years 2-4

October 1, 2013 - September 30, 2016
ED 158
Université Pierre et Marie Curie

Ontogenic and functional characterization of the innate immune response toneurodegeneration in Parkinson disease.

HIRSCH Etienne

Year 1

October 1, 2012 - June 1, 2013
UEI (Unité d'Enseignement isolé)
Université Pierre et Marie Curie

Lab rot 1Role of spatacsin and spastizin, two proteins implicated in hereditary spastic paraplegias, in linking endoplasmic reticulum with microtubules.

Lab rot 2Development of a parabiosis-based chimeric model to investigate blood-born monocyte infiltration into the pathological CNS of Parkinson disease mice.

BRICE Alexis
HIRSCH Etienne



Fuentealba J, Toro-Tapia G, Arriagada C, Riquelme L, Beyer A, Henriquez JP, Caprile T, Mayor R, Marcellini S, Hinrichs MV, Olate J, Torrejón M. Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration. Dev Biol. 2013 Jun 15;378(2):74-82. doi: 10.1016/j.ydbio.2013.04.005. PMID: 23588098 

Bertrand S, Fuentealba J, Aze A, Hudson C, Yasuo H, Torrejon M, Escriva H, Marcellini S. A dynamic history of gene duplications and losses characterizes the evolution of the SPARC family in eumetazoans. Proc Biol Sci. 2013 Feb 27;280(1757):20122963. doi: 10.1098/rspb.2012.2963. PMID: 23446527

Maldonado-Agurto R, Toro G, Fuentealba J, Arriagada C, Campos T, Albistur M, Henriquez JP, Olate J, Hinrichs MV, Torrejón M. Cloning and spatiotemporal expression of RIC-8 in Xenopus embryogenesis. Gene Expr Patterns. 2011 Oct;11(7):401-8. doi: 10.1016/j.gep.2011.06.001. PMID: 21726669


Etienne HIRSCH
Our project is driven by two major complementary objectives: 1) to characterize the mechanisms involved in the progression of nerve cell death in neurodegenerative disorders and especially Parkinson’...