A neuron-machine interface based on dynamic-clamp allows building hybrid circuits, in which living neurons interact in real time with computer models via artificial synapses: 1) We explore the top-down cortical mechanisms of sensory information transfer in thalamocortical circuits at different scales: from the cellular and conductance levels to the mesoscopic level of the population of neurons. 2) We unraveled the post-synaptic sensors of synaptic activity involved in the retrograde control of neurotransmitter release and the homeostasis of the neuromuscular transmission (G. Ouanounou). 3) We contributed with A. Destexhe team to the development of methods of estimation of conductances and other properties of network activity from intracellular recordings. 4) We are installing a voltage sensitive imaging technique with exceptional spatial and temporal resolution to monitor the propagation of fast electrical events into fine axon collaterals and dendrites in individual neurons in vitro. Combining these techniques will increase the technical sophistication of the mixed theoretical/experimental investigations performed through interdisciplinary collaboration in the UNIC lab. In particular, we are examining the cellular origin of magnetic field generators and local field potentials in cells and circuits.