Junctional communication and neuro-glio-vascular interactions

Institution

Collège de France
CNRS
Inserm
ED158
Université Pierre et Marie Curie

Laboratory

Center for Interdisciplinary Research in Biology
Phone: 01 44 27 12 22
UMR7241-U1050
Labex Memolife- PSL

Keywords

Glial cells
astrocytes
 

Publications

Koulakoff A., Mei X., Orellana J.A., Sáez J.C. & Giaume C. Glial connexin expression and function in the context of Alzheimer's disease. Biochimica Biophysica Acta, 1818:2048-57. (2012)

Ezan P., André P., Cisternino S., Saubaméa B., Boulay A.C., Doutremer S., Thomas M.A., Quenech'du N., Giaume C. & Cohen-Salmon M. Deletion of astroglial connexins weakens the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 32:1457-67.(2012)

Roux L., Benchenane K., Rothstein J.D., Bonvento G. & Giaume C. Plasticity of astroglial networks in olfactory glomeruli. Proceedings of theNational Academy of Sciences (USA),108:18442-6. (2011)

Orellana J.A., Shoji K.F., Abudara V., Ezan P., Amigou E., Sáez P.J., Jiang J.X., Naus C.C., Sáez J.C. & Giaume C. Amyloid β-induced death in neurons involves glial and neuronal hemichannels.Journal of Neuroscience, 31:4962-77.(2011),

Giaume C., Koulakoff A., Roux L., Holcman D. & Rouach N. Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci, 11:87-99. (2010)

Fields of research

Neuropharmacology / cell signaling

Research Theme

The main focus of our projects concerns the network organization of glial cells, in particular astrocytes, as the result of their high expression level of connexins, the gap junction proteins. These projects are considered in the context of the interactions between astrocytes and neurons as well as at the gliovascular interface. Indeed, it is now recognized that astrocytes interact dynamically with neurons and can modify their activity and survival, but so far such interactions are only considered as contributed by individual cells. Our strategy is to study these interactions at a more integrated level as the result of interactions between neuronal circuits and astroglial networks. As astrocytes “endfeet” surround blood vessels and express a large number of connexins at their contacts, we are also interested in understanding their role at the gliovascular interface and the blood brain barrier. Our research also covers pathological situations, as there is evidence indicating that neuroglial interactions contribute to epileptic-like activities in neurons. Finally, we are also interested in a transgenic animal model of Alzheimer’s disease (APP/PS1) in which we have observed that the expression of the two astrocytic connexins is upregulated at the level of amyloid plaques.

Team members

Cohen-Salmon Martine
Koulakoff Annette